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EC number: 939-409-2 | CAS number: 1329-99-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14.12.1984-19.12.1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to GLP and valid methods, however few data were available on test substance composition. Nevertheless it is considered relevant, reliable and adequate for classification.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction mass of 1-Methyl-4-(1-methylethenyl)cyclohexene and 1-Methyl-4-(1-methylethylidene)-cyclohexene and 1-methyl-4-(propan-2-yl)cyclohexa-1,3-diene
- EC Number:
- 939-409-2
- Cas Number:
- 1329-99-3
- Molecular formula:
- C10H16
- IUPAC Name:
- Reaction mass of 1-Methyl-4-(1-methylethenyl)cyclohexene and 1-Methyl-4-(1-methylethylidene)-cyclohexene and 1-methyl-4-(propan-2-yl)cyclohexa-1,3-diene
- Reference substance name:
- Isopropylmethylcyclohexane, tetradehydro derivative
- EC Number:
- 215-532-0
- EC Name:
- Isopropylmethylcyclohexane, tetradehydro derivative
- Cas Number:
- 1329-99-3
- IUPAC Name:
- 1-isopropyl-4-methylcyclohexane
- Test material form:
- other: liquid
- Details on test material:
- The compound Depanol J is a colourless liquid. It was received at C.I.T. on the 23.11.84 in a plastic flask under the reference "Depanol J".
Note by CABB GmbH: handwritten notice of the plant manager, 'Depanol I' misread as 'Depanol J'.
A substance 'Depanol J' was never produced by Hoechst nor by subsequent companies.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: Albino New Zealand, Hy / Cr
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River France (76410 Saint Aubin les Elbeuf, France)
- Weight at study initiation: 2410 g mean weight
- Housing: Individually in polystyrene cages (0.35 x 0.55 x 0.32 m); each cage was equipped with a food container and a water bottle.
- Diet (e.g. ad libitum): Ad libitum with a certified pelleted diet Rabbit Diet SQC (Special Diets Services Ltd, Witham, Essex England)
- Water (e.g. ad libitum): Tap water filtered with Millipore filters in water bottles ad libitum
- Acclimation period: At least 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 ± 3 °C
- Humidity (%): 50% ± 30%
- Air changes (per hr): No data (The incoming, non-recycled air, was filtered by an absolute filter.)
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4 days
- Number of animals:
- 6 males
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm2 of the back and flanks
- % coverage: Not provided
- Type of wrap if used: The treated area was covered with a hydrophilic gauze patch (Codex) to prevent loss of test material. The test material and the gauze patch were held in contact with the skin with a semi-occlusive patch adhesive tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No
SCORING SYSTEM: See under "Any other information on material and methods incl. tables"
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hour
- Score:
- 1.84
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 hour
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 hour
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: animal found dead day 4
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72 hour
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- other: 24, 48, 72 hour
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- other: 24, 48, 72 hour
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- other: 24, 48, 72 hour
- Score:
- 2.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hour
- Score:
- 0.39
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 hour
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 hour
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: animal found dead day 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72 hour
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- other: 24, 48, 72 hour
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- other: 24, 48, 72 hour
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- other: 24, 48, 72 hour
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
Any other information on results incl. tables
Evaluation of skin reactions
|
Rabbit |
D1 |
D2 |
D3 |
D4 |
D5 |
Erythema |
01 |
1 |
2 |
2 |
1 |
0 |
02 |
1 |
2 |
2 |
- |
- |
|
03 |
2 |
2 |
2 |
2 |
0 |
|
04 |
2 |
1 |
1 |
1 |
0 |
|
05 |
3 |
3 |
2 |
0 |
- |
|
06 |
2 |
3 |
3 |
2 |
0 |
|
Oedema |
01 |
1 |
1 |
0 |
0 |
0 |
02 |
1 |
1 |
0 |
- |
- |
|
03 |
1 |
1 |
0 |
0 |
0 |
|
04 |
1 |
0 |
0 |
0 |
0 |
|
05 |
2 |
1 |
1 |
0 |
- |
|
06 |
1 |
1 |
1 |
0 |
0 |
The animal no. 02 was found dead on Day 4
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under these experimental conditions and according to the directive 83/467 EEC concerning classification, the packing and the labeling of the dangerous substances, the compound was considered as non-irritant.
- Executive summary:
An acute dermal irritation study was performed with the compound Depanol I in six New-Zealand rabbits, according to the OECD Guideline No. 404 and the OECD Guideline for Good Laboratory Practice.
Erythema and oedema were observed in all animals one hour after instillation (very slight to moderate erythema and very slight to slight oedema). Oedema disappeared from Day 2 to Day 4 and erythema from Day 4 to Day 5.
Under these experimental conditions and according to the Directive 83/467 EEC concerning classification, the packing and the labeling of the dangerous substances, the compound was considered as non-irritant.
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