Registration Dossier
Registration Dossier
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EC number: 211-059-9 | CAS number: 628-89-7
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- R: QSAR Toolbox 3.0."Human Health Hazards#Toxicokinetics, Metabolism and Distribution#Basic Toxicokinetics" for 628-89-7
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- QSAR Toolbox version 3
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 417 (Toxicokinetics);EPA OPPTS 870.8320 (Oral/dermal pharmacokinetics)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-(2-chloroethoxy)ethanol
- EC Number:
- 211-059-9
- EC Name:
- 2-(2-chloroethoxy)ethanol
- Cas Number:
- 628-89-7
- Molecular formula:
- C4H9ClO2
- IUPAC Name:
- 2-(2-chloroethoxy)ethan-1-ol
- Details on test material:
- SMILES:C(Cl)COCCO
Constituent 1
Test animals
- Species:
- other: rat;mouse;human;guinea pig;rabbit
- Strain:
- other: Sprague-Dawley;Fischer 344;B6C3F1;not applicable;outbred strain;Wistar;"Sprague-Dawley; BDIX";New Zealand White
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- other: Not applicable. in vitro study;oral: gavage;inhalation;dermal vapour;intravenous;inhalation: vapour;ip, oral and inhalation of vapour;dermal;intraperitoneal;i.v. and oral
Results and discussion
Any other information on results incl. tables
Estimation
method: Takes mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((("a"
and "b")and
"c")and("d"
and "e"))
Domain
logical expression index: "a"
Referential
boundary:The
target chemical should be classified as Nonionic Surfactants by US-EPA
New Chemical Categories
Domain
logical expression index: "b"
Similarity
boundary:Target:
C(Cl)COCCO
Threshold=50%,
Dice(Atom centered fragments)
Domain
logical expression index: "c"
Similarity
boundary:Target:
C(Cl)COCCO
Threshold=50%,
Dice(Atom centered fragments)
Domain
logical expression index: "d"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -0.692
Domain
logical expression index: "e"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 1.55
Applicant's summary and conclusion
- Conclusions:
- no bioaccumulation potential based on study results
- Executive summary:
No bioaccumulation potential based on study results.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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