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Diss Factsheets
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EC number: 247-477-3 | CAS number: 26140-60-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
Fish:
The acute toxicity studies on fish indicate that rainbow trout is more sensitive towards the chemical in comparison to fathead minnow. The EC50 values for Pimephalis promelas were above the highest nominal test concentration in both cases >1000 mg/L (and thus far above the solubility of the test substance), while the EC50 value for Salmo gairdneri was determined at 27 mg/L. Additionally, there is a long-term fish on fish larvae (Pimephales promelas) is available. Three endpoints were evaluated: embryo survival at hatch, growth (weight and length after 30d) and larval survival (for 30 d) of which survival of the larvae was the most sensitive endpoint displayed (NOEC = 37 µg/l). These results indicate that there is a large difference between the acute and chronic toxicity towards this substance for fish.
Invertebrates:
The acute toxicity assays on invertebrates indicate that the crustaceans are more or less equally sensitive, while the insecta are clearly less sensitive. Additionally, the test results indicate that there is a clear difference in toxicity depending on the composition of the chemical. Comparing the toxicity of the individual terphenyls, p-terphenyl is not toxic in the tested range (EC50 48h > 5500µg/L), while the other two (ortho and para) are toxic in the low µg-range (EC50 48h of 45 and 22 µg/L for the ortho- and meta-isomer respectively). This difference is most probably caused by the difference in water solubility between the different isomers, with the p-isomer having the lowest water solubility. This also suggests that the toxicity of the terphenyl mixtures can be very different according to the composition of the multi-constituent, the higher the amount of ortho- and meta-terphenyl, the higher the expected toxicity. As interspecies differences and differences in toxicity according to composition are prominent as a worst case the study on the effect of m-terphenyl to Daphnia is chosen as a key study (EC50 = 22 µg/l). The lowest value was found for MCS-1980, but this was not confirmed by a second test on MCF1980new.
These short-term toxicity results could be compared to the results from a long-term toxicity in Daphnia magna (Therminol 75). The assessed endpoints were survival and reproducation after 21 days of exposure. The NOECs for those endpoints were 0.007 and 0.0048 mg/L respectively. These results indicate that the difference in toxicity between the acute and chronic toxicity tests is not that different for invertebrates such as Daphnia magna.
Algae:
Several tests describing the toxicity towards algae are available and all indicate that the substance is rather toxic towards algae. The two studies which are most recently performed (Santowax R) tested up to 24.8 µg/l test substance. No effects on growth rate were seen at this test concentration, thus the NOEC based on growth rate (72h) was above 24.8 µg/l in one of the tests, the NOEC for biomass in the other test was however 3.22 µg/l (72h). The other tests on Therminol 88 and Therminol 75 reported effect levels in the same range of toxicity, the endpoint however was not growth rate but biomass (and reported 96h instead of 72h) and therfore preference is given to the two studies on Santowax R. In this study the lowest NOEC value of 3.22 µg/l was reported.
Conclusion:
Based on the acute toxicity data, fish are clearly the least sensitive organisms, invertebrates and algae appear to be in the same toxicity range. The long-term toxicity data however indicate that the substance displays toxicity towards all organims. Although there is a certain decrease in toxicity going from fish to invertebrates and then algae shown by their respective NOECs of 37, 4.8 and 3.22 µg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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