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EC number: 238-735-6 | CAS number: 14691-80-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Publication, data reported at summary level.
- Justification for type of information:
- Study submitted on analogous substance as supporting data only.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
- Objective of study:
- other: Intestinal resorption, excretion and balance of phosphates with different chain length
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Mini-pigs were fed basic diets supplemented with 4 different phosphates of increasing chain length. The balance of uptake and excretion via urine and faeces was determined over period of 22 - 26 days.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tetrasodium pyrophosphate
- EC Number:
- 231-767-1
- EC Name:
- Tetrasodium pyrophosphate
- Cas Number:
- 7722-88-5
- Molecular formula:
- Na4P2O7
- IUPAC Name:
- tetrasodium phosphonato phosphate
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Tetrasodium pyrophosphate (Na4P2O7)
- Other substances tested: Disodium hydrogen phosphate (Na2HPO4), Sodium polyphosphate (Na5P3O10), Graham Salt ((NPO3)x)
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- pig
- Strain:
- other: Göttingen miniature pigs
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Duration and frequency of treatment / exposure:
- Pre-period: 2 - 6 days
Supplemental phase I: 6 - 7 days
Supplemental phase II: 3 - 7 days
Supplemental phase III: 4 - 5 days
Post phase: 3 - 4 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.9 - 3.6 g per animal and day
- No. of animals per sex per dose / concentration:
- 8
- Control animals:
- no
Results and discussion
- Preliminary studies:
- No studies reported.
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- See Table 1 and 2
Any other information on results incl. tables
Essentially there was an equilibrated balance between intake and excretion.
Table 1 shows that the urinary excretion of higher linear condensed phosphates is lower, indicating a lower intestinal resorption.
Table 1: Uptake and urinary excretion of phosphates of different phosphate supplements
Supplement | Additional excretion |
Average | ||
(g P/day | (g P/day) | (%) | (%) |
|
Na2HPO4 | 1.0 | 0.18 | 18 | |
3.2 | 0.71 | 23 | 21.6 |
|
2.2 | 0.53 | 24 | ||
Na4P2O7 | 1.2 | 0.21 | 18 | |
3.6 | 0.69 | 19 | 22.0 |
|
2.2 | 0.64 | 29 | ||
Na5P3O10 | 1.2 | 0.25 | 21 | |
3.3 | 0.66 | 20 | 22.3 |
|
2,1 | 0.53 | 26 | ||
(NaPO3)x | 0.9 | 0.04 | 5 | |
2.9 | 0.33 | 11 | 9.8 |
|
2.0 | 0.20 | 13 |
Table 2 shows the equilibrated balances. Again, in the polycondensed phosphates the decreasing urinary while increasing fecal excretion points to a reduced intestinal resorption.
Table 2: Balance of phosphates (per animal and day) per period, all values in g/day
TrialPeriod | Phosph. | Phosph. Excretion |
Balance | |||
Input | Urine | Feces | ||||
Trial I | pre period | 1.82 | 0.37 | 1.56 | -0.11 | |
NaHPO4 | 1. Supplement | 2.83 | 0.55 | 2.30 | -0.02 | |
2. Supplement | 5.20 | 1.09 | 3.60 | +0.51 | ||
3. Supplement | 4.04 | 0.90 | 3.25 | -0.11 | ||
post period | 1.82 | 0.43 | 1.85 | -0.26 | ||
Trial II | pre period | 1.72 | 0.32 | 1.50 | -0.10 | |
Na4P2O5 | 1. Supplement | 2.94 | 0.53 | 2.32 | +0.08 | |
2. Supplement | 5.36 | 1.01 | 3.40 | +0.94 | ||
3. Supplement | 3.91 | 0.96 | 2.84 | +0.10 | ||
post period | 1.72 | 0.38 | 1.72 | -0.37 | ||
Trial III | pre period | 1.98 | 0.32 | 1.70 | -0.04 | |
Na5 P3O10 | 1. Supplement | 3.15 | 0.56 | 2.48 | +0.11 | |
2. Supplement | 5.25 | 0.98 | 4.12 | +0.15 | ||
3. Supplement | 4.08 | 0.85 | 3.29 | -0.06 | ||
post period | 1.98 | 0.50 | 1.67 | -0.19 | ||
Trial IV | pre period | 1.98 | 0.39 | 1.84 | -0.24 | |
(NaPO3)x | 1. Supplement | 2.85 | 0.43 | 2.39 | +0.04 | |
2. Supplement | 4.89 | 0.72 | 4.04 | +0.14 | ||
3. Supplement | 4.02 | 0.65 | 3.29 | +0.08 | ||
post period | 1.98 | 0.42 | 1.58 | -0.02 |
The conclusion is that increasing phosphate input induces increased phosphate output in an equilibrated fashion. The phosphate, calcium and magnesium levels in serum were not altered. The dose of up to 5 g phosphate/animal/day is considered as high.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Doses of up to 5 g phosphorous/animal/day in the form of 4 different sources (disodium hydrogen phosphate, tetrasodium pyrophosphate, sodium tripolyphosphate or Graham salt) resulted in an equilibrated balance and were well tolerated. With longer P chains the intestinal resorption appears to decrease. - Executive summary:
Eight adult male minipigs were offered a commercial low phosphorous basic diet which was supplemented over 3 trial periods (4 - 7 days each) with either disodium hydrogen phosphate, tetrasodium pyrophosphate, sodium tripolyphosphate or Graham salt at a dose of 0.9 - 3.6 g/animal/day.
From the determinations of phosphorous in diet, feces and urine, it was concluded that, independent of the length of the polyphosphate chain, output and intake were equilibrated. With long-chain phosphate at high doses, a lower urinary P excretion corresponds with higher fecal P excretion.
The animals adapted well to the increased phoshorous diet.
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