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Diss Factsheets
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EC number: 225-862-7 | CAS number: 5124-25-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- Comparable to international accepted guidelines.
- Principles of method if other than guideline:
- Method A-11
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- None
- Analytical monitoring:
- not specified
- Details on sampling:
- Not available
- Vehicle:
- not specified
- Details on test solutions:
- No data
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: zebra fish - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- No data
- Hardness:
- No data
- Test temperature:
- 23 °C
- pH:
- 8.3-8.4
- Dissolved oxygen:
- 92-96 %
- Salinity:
- No data
- Nominal and measured concentrations:
- Nominal: 100, 300 and 1000 mg/L
- Details on test conditions:
- No data
- Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 300 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- ca. 162 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 540 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 540 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Details on results:
- At 96 hrs: 10/10 fishes survived at 100 and 300 mg/L. 9/10 fishes survived at 1000 mg/L.
- Results with reference substance (positive control):
- No data
- Reported statistics and error estimates:
- No data
- Sublethal observations / clinical signs:
Concentration
(mg/L)Surviving fish pH O2
(%)1 h 4 h 24 h 48 h 72 h 96 h 100 10 10 10 10 10 10 8.4 96 300 10 10 10 10 10 10 8.4 94 1000 10 10 10 10 10 9 8.3 92 - Validity criteria fulfilled:
- not specified
- Conclusions:
- Under the test conditions, the 96 h LC0 for zebra fish (Danio rerio) was 300 mg/L (i.e. ca. 162 mg a.i./L), while the 96 h LC50 and LC100 were both >1000 mg/L (i.e. ca. >540 mg a.i./L).
- Executive summary:
A study was conducted according to guideline similar to OECD TG 202 to determine the acute toxicity of the test substance to zebra fish (Danio rerio). Groups of 10 fish were exposed at 100, 300 or 1000 mg/L for a duration of 96 h. The number of surviving fish was recorded at 1, 4, 24, 48, 72 and 96 h. At 96 hrs: 10/10 fishes survived at 100 and 300 mg/L. 9/10 fishes survived at 1000 mg/L. Under the test conditions, the 96 h LC0 was 300 mg/L (i.e. ca. 162 mg a.i./L), while the 96 h LC50 and LC100 were both >1000 mg/L (i.e. ca. > 540 mg a.i./L).
Reference
Description of key information
A study was conducted to determine the acute toxicity of the test substance to zebra fish (Danio rerio). Groups of 10 fish were exposed at 100, 300 or 1000 mg/L for a duration of 96 h. The number of surviving fish was recorded at 1, 4, 24, 48, 72 and 96 h. There was no mortality at 100 or 300 mg/L. One fish died within 96 h at 1000 mg/L. Under the test conditions, the 96 h LC0 was 300 mg/L (i.e. ca. 162 mg a.i./L), while the 96 h LC50 and LC100 were both >1000 mg/L (i.e. ca. >540 mg a.i./L). A few more studies performed during 1983, 1975, 1973 have reported TL50 (96 h) >1000 mg/l , >45 mg/L, and 140 mg/L. A 1990 study reported LC50 (96 h) to Zebra fish as >1000 mg/l. In conclusion, the test item FAT 36014 had no acute toxic effects on zebra fish under the present test conditions.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 000 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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