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EC number: 231-388-1 | CAS number: 7526-26-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Predicted NOAEL of 318 mg/kg bw.
A 28 Day Oral Gavage Toxicity Study in the Rat (without recovery; according to OECD 407 / OPPTS 870.3050 / EC B.7 / GLP) has been ordered in a CRO to improve the dataset for this endpoint and have a more robust point-of-departure for the DNEL derivation.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD Toolbox 2.2, is a harmonized system for OSAR application and grouping chemicals into categories, whose OECD principles are met
- Qualifier:
- according to guideline
- Guideline:
- other: CSCL; CSCL, OECD TG409; CSCL, OECD TG 407; CSCL, OECD TG408; CSCL, OECD TG410; OECD TG 422
- Principles of method if other than guideline:
- Prediction by the OECD QSAR Toolbox (read-across approach)
- GLP compliance:
- not specified
- Limit test:
- no
- Species:
- other: rat;mouse
- Strain:
- other: Wistar; Crj:CD(SD); Sprague-Dawley; no data; CD-1;F344; B6C3F1
- Sex:
- not specified
- Dose descriptor:
- other: "Effect LOEL", LOEL, NOEC, NOEL, "Study LOEL", "Study NOEL"
- Effect level:
- 318 mg/kg bw/day (nominal)
- Basis for effect level:
- other: taking the average from the nearest 5 neighbours, based on 5 data points from 5 neighbour chemicals
- Critical effects observed:
- not specified
- Conclusions:
- A NOAEL for the target chemical is considered to be 318 mg/kg bw. An assessment factor of 5 has to be applied due to uncertainties arisen from data base quality (4 of 5 category members are phosphates).
- Executive summary:
The chemical diphenyl methylphosphonate (CAS 7526 -26 -3) was evaluated by the OECD QSAR Toolbox software for its level of toxicity by the prolonged exposure. The prediction was based on the measured values of chemicals assigned into the category.
The target chemical was classified as "Esters, Esters (phosphates)" by the profiling method "Aquatic toxicity classification by ECOSAR". Therefore, primarily a search for chemicals with the same classification was performed. Thereafter, a refinement to eliminate the chemicals which do have other chemical elements was perfomed. Finally, the chemicals were subcategorized according to their structural similarity. Four chemicals used for read-across were phosphates while only one chemical is phosphonate.
A LOAEL of 318 mg/kg bw was calculated for the target chemical (as average of the experimentally obtained LOEL, effect LOEL, LOEL etc. of the analogues). An assessment factor of 5 has to be applied to the calculated value to obtain a NOAEL which can cover uncertainties arisen from a data base quality.
Reference
The
prediction was based on dataset comprised from the following
descriptors: "effect LOEL","study NOEL","study LOEL",NOEL,LOEL
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression: Result: In Domain
((("a"
and ("b"
and (
not "c")
)
)
and "d" )
and ("e"
and "f" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Esters AND Esters (phosphate) by
Aquatic toxicity classification by ECOSAR ONLY
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Group 14 - Carbon C AND Group 15
- Phosphorus P AND Group 16 - Oxygen O by Chemical elements
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Group 15 - Nitrogen N OR Group
16 - Sulfur S OR Group 17 - Halogens F,Cl,Br,I,At by Chemical elements
Domain
logical expression index: "d"
Similarity
boundary:Target:
c1(OP(C)(=O)Oc2ccccc2)ccccc1
Threshold=50%,
Dice(Atom pairs)
Domain
logical expression index: "e"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -0.156
Domain
logical expression index: "f"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 5.25
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 318 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- 4 of 5 category members are phosphates while DPP is a phosphonate. An additional assessment factor of 5 is proposed to cover uncertainties due to the read-across.
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There are no repeated dose toxicity studies available for Diphenyl methylphosphonate. The studies are waived due to the fact that no relevant exposure to humans exists (please refer to waiver). Therefore, the chemical Diphenyl methylphosphonate (CAS 7526 -26 -3) was evaluated by the OECD QSAR Toolbox software for its level of toxicity by the prolonged exposure in order to have a NOAEL/LOAEL for the derivation of DNELs. The prediction was based on the measured values of chemicals assigned into the category.
The target chemical was classified as "Esters, Esters (phosphates)" by the profiling method "Aquatic toxicity classification by ECOSAR". Therefore, primarily a search for chemicals with the same classification was performed. Thereafter, a refinement to eliminate the chemicals which possess other chemical elements was performed. Finally, the chemicals were subcategorized according to their structural similarity. Four chemicals used for read-across were phosphates while only one chemical is phosphonate.
A LOAEL of 318 mg/kg bw was calculated for the target chemical (as average of the experimentally obtained LOEL, effect LOEL, LOEL etc. of the analogues). For hazardous risk assessment (derivation of DNEL), an assessment factor of 5 has to be applied to the predicted LOAEL.
Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
Acceptable, recommended by ECHA software for grouping chemicals into categories and read-across.
Justification for classification or non-classification
The registered substance is not subject for classification and labelling for STOT-RE according to Regulation (EC) No 1272/2008 since the read-across chemicals are not classified for this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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