Registration Dossier
Registration Dossier
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EC number: 236-826-5 | CAS number: 13499-05-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study not performed according to GLP but data are well documented and scientifically acceptable
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- The toxicologic and pharmacologic effects of hafnium salts
- Author:
- Haley T.J., Raymond K., Komesu N. and Upham H.C.
- Year:
- 1 962
- Bibliographic source:
- Toxicology and applied pharmacology, vol 4: 238-246
Materials and methods
- Principles of method if other than guideline:
- Three rabbits received 1 mg of hafnium chloride placed in one eye.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- hafnyl chloride (HfOCl2)
- IUPAC Name:
- hafnyl chloride (HfOCl2)
- Test material form:
- not specified
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Observation period (in vivo):
- 24 hours
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
- Irritant / corrosive response data:
- This exposition resulted in an immediate increase in the rate of blinking and a redness of the palpebral conjunctiva within 1 hour.
At 24 hours, there was no evidence of corneal or iris damages, conjuctival irritation, chemosis or increased lacrimal discharge.
According to the author, the natural buffering capacity of the lacrimal fluid was sufficient to counteract the nascent hydrochloric acid released when the hafnium chloride dissolved in the lacrimal fluids.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
Three rabbits had 1 mg of hafnium chloride placed in one eye to complete the study of ocular irritation. This exposition resulted in an immediate increase in the rate of blinking and a redness of the palpebral conjunctiva within 1 hour. At 24 hours, there was no evidence of corneal or iris damages, conjuctival irritation, chemosis or increased lacrimal discharge. According to the author, the natural buffering capacity of the lacrimal fluid was sufficient to counteract the nascent hydrochloric acid released when the hafnium chloride dissolved in the lacrimal fluids.
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