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Diss Factsheets
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EC number: 939-270-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The UVCB substance to be registered is a mixture of the two Guerbet alcohols 2 -hexyldecan-1-ol & 2-octyldodecan-1 -ol and their corresponding esters with C12 and C14 fatty acids. Skin sensitization studies are not available for the UVCB substance. The skin sensitizing potential is evaluated on the basis of experimental data for Guerbet alcohols and esters of branched alcohols with fatty acids.
Of these two substance classes present in the UVCB substance, the Guerbet alcohols are considered to have the higher impact on the toxicological evaluation, for the following reasons:
- The two Guerbet alcohols are the major components in the UVCB substance, accounting for appr. 30-50%
- The ester components are expected to be metabolized to fatty acids and the two free Guerbet alcohols, thus contributing to the fraction of Guerbet alcohols
- In comparison to the Guerbet alcohol esters, the free Guerbet alcohols have a lower molecular weight, which would favor their uptake (a prerequisite for the induction of skin sensitizing effects)
- Having a free functional group, the Guerbet alcohols are more prone to undergo physiological reactions
Data on skin sensitisation are presented for 2 -octyl-dodecanol, a mixture of the two C20 isomers 2-octyldodecan-1-ol and 2 -hexyltetradecan-1-ol, and the reaction product of 2-ethylhexanol with C8-16 fatty acids. The latter is a close homologues to the esters in the UVCB substance, with a very similar fatty acid pattern, but an alcoholic structure which differs in the chain length (close homologue: C8 branched alcohol, esters in the UVCB substance: C16 or C20 branched alcohol). Due to these minor structural variations, the data for the close homologue can be considered for the evaluation of the skin sensitization potential of the ester components in the UVCB substance.
All tested substances exhibited no skin sensitising effects in Guinea pig maximization tests. Additional information is available for the category of Guerbet alcohols, as the REACH consortium in charge has evaluated the sensitization potential of the whole category on a broader data basis. It was concluded that the category of Guerbet alcohols is not suspected to induce skin sensitisation.
Altogether, no skin sensitizing potential is expected for Guerbet alcohols and their esters with C8 -16 fatty acids on the basis of all available information.
Justification for selection of skin sensitisation endpoint:
Based on the lower molecular weight and the higher predicted dermal absorption (modeled with DERMWIN (v1.43)), which is a prerequisite for the induction of skin sensitisation, the free Guerbet alcohol was considered to be the worst case compared to the reaction product of 2-ethylhexanol with C8-16 fatty acids.
The study was furthermore conducted according to guideline (Klimisch 1).
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
no data available
Justification for classification or non-classification
Available data are conclusive but not sufficient for classfication of 2-hexyldecan-1-ol with regard to skin sensitisation.
There are data lacking for the classification of 2-hexyldecan-1-ol with regard to respiratory sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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