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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test methodology according to a standard protocol in a reliable corporate laboratory, but not performed under GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1994

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: U.S. 49 CFR Subpart D, 173, 136-137
Deviations:
no
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-vinylpyridine
EC Number:
202-852-0
EC Name:
4-vinylpyridine
Cas Number:
100-43-6
Molecular formula:
C7H7N
IUPAC Name:
4-ethenylpyridine
Test material form:
other: clear liquid
Details on test material:
Tested as received

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
After acclimation, 6 NZW rabbits (3 males/3 females) were identified by a number allocated to each on receipt and stainless steel ear tag bearing this number. They were selected after a 10 day rest period. They were caged individually in suspended stainless steel cages with mesh floors. Room temperature was 70-73 degrees F. Food was Purina Rabbit Chow. Water was filtered tap water supplied by an automatic water system.

Test system

Type of coverage:
occlusive
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
0.5 ml of test material applied to a 2.5 cm2 intact site.
Duration of treatment / exposure:
3 minutes or 1 hour
Observation period:
48 hours
Number of animals:
6 animals
Details on study design:
TEST SITE
- Area of exposure: 2.5 cm2
- % coverage:
- Type of wrap if used: 2 x 2 in adhesive-backed gauze patch, secured in place with 2 inch non-irritating Durapore tape to minimize evaporation.

REMOVAL OF TEST SUBSTANCE
- Washing (if done): wiped clean to prevent further exposure
- Time after start of exposure: 3 minutes or 1 hour

SCORING SYSTEM: Evaluation of corrosion: presence of destruction or irreversible alteration of the tissue in at least 2 of 6 animals. Tissue destruction was considered to have occurred if there was ulceration and/or necrosis.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: corrosion
Basis:
other: Considered positive if 2 of 6 animals showed corrosion.
Time point:
other: 48 hours after administration
Score:
0
Max. score:
6
Remarks on result:
other: No corrosion evident after a 3 minute exposure
Irritation parameter:
other: Corrosion
Basis:
other: Considered positive if 2 of 6 animals showed corrosion.
Time point:
other: 48 hours
Score:
3
Max. score:
6
Reversibility:
not reversible
Remarks on result:
other: 3 of 6 animals showed corrosion after a 1 hour exposure
Irritant / corrosive response data:
4-Vinylpyridine is considered corrosive when evaluated 48 hours after a 1 hour exposure

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
4 -Vinylpyridine was corrosive to the skin of rabbits after a 1 hour exposure. This meets the criteria of CLP Category 1B.