Registration Dossier
Registration Dossier
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EC number: 219-340-8 | CAS number: 2420-17-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Result with Benzylhydantoin (BHT): Ames negative with or without metabolic activation (S. typhimurium and E. coli)
Read-across from Benzylhydantoin, or 5-(phenylmethyl)imidazolidine-2,4-dione (CAS n° 3530-82-3) to HPG-hyd: p-hydroxy-phenylhydantoin, or 5-(4-hydroxyphenyl)imidazolidine-2,4-dione is supported, beyond an obvious structural similarity, by the following mechanistic criteria similarities, as evaluated by the OECD Toolbox:
- Benigni-Rossa rule base: no structural alert (for carcinogenicity)
- DNA binding: ureide structural alert group
- Protein binding: potentially can cause skin sensitization as a result of protein conjugation via nucleophilic substitution of cyclic dicarbonyls
Short description of key information:
By analogy with Benzylhydantoin (or 5-(phenylmethyl)imidazolidine-2,4-dione, CAS n° 3530-82-3), p-Hydroxy-phenylhydantoin (HPG-hyd) is not considered to be genotoxic substance.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Data are conclusive for genetic toxicity, but not sufficient for classification according to CLP criteria (Regulation (EC) No 1272/2008).No data is available in mammalian cells in-vitro.
No classification is proposed for genetic toxicity according to CLP criteria.
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