Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-764-3 | CAS number: 2526-62-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
No data are available for the submission substance, 3-(trimethoxysilyl)propiononitrile (CAS 2526-62-7). However, data are available for the structurally-analogous substance, 3-(triethoxysilyl)propiononitrile (CAS 919-31-3). The two substances share a common hydrolysis product.
Reliable short-term toxicity tests results are available for freshwater fish (Oncorhynchus mykiss), invertebrates (Daphnia magna) and algae (Pseudokirchneriella subcapitata).
The relevant values are:
Fish: LC50 (96 h): >110 mg/l (measured concentration of parent test substance).
Daphnia: EC50 (48 h): >100 mg/l (measured concentration of parent test substance).
Algae: ErC50 (72 h): >120 mg/l; ErC10: >120 mg/l; NOEC: 60 mg/l (nominal concentration) or >74 mg/l, >74 mg/l and 37 mg/l, respectively, expressed in terms of concentration of the hydrolysis product, 3-(trihydroxysilyl)propiononitrile.
It is likely that under the flow-through conditions for the fish and invertebrate tests, the test organisms were exposed to primarily the parent read-across substance, 3-(triethoxysilyl)propiononitrile, and minor quantities of its hydrolysis products, 3-(trihydroxysilyl)propiononitrile and ethanol. While in the static algal test it is likely that the test organisms were exposed to a mixture of the parent substance and its hydrolysis products.
The read-across is supported by the Quantitative Structure Activity Relationship (QSAR) predictions for the silanol hydrolysis product, 3-(trihydroxysilyl)propiononitrile. Fish, invertebrate and algal E(L)C50 values have been estimated. The relevant values are:
Fish QSAR: LC50 (96 h): 2 800 000 mg/l.
Daphnia QSAR: EC50 (48 h): 990 000 mg/l.
Algae QSAR: EC50 (96 h): 110 000 mg/l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.