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EC number: 200-908-9 | CAS number: 75-85-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1977-5-25 to 1981-04-15
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1981
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methylbutan-2-ol
- EC Number:
- 200-908-9
- EC Name:
- 2-methylbutan-2-ol
- Cas Number:
- 75-85-4
- Molecular formula:
- C5H12O
- IUPAC Name:
- 2-methylbutan-2-ol
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: mice, rats and dogs
- Strain:
- other: CD1-mice, Fischer rats and beagle dogs
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Sex: Mice and rats: males and females; dogs: males
- Source:
mice: Charles River Breeding Laboratories, Wilmington, MA, USA;
rats: Charles River Breeding Laboratories, Portage, MI, USA;
dogs: Laboratory Research Enterprises, Kalamazoo, MI, USA
- Age at study initiation:
mice: app. 4 weeks
rats: app. 5 weeks;
dogs: app. 10 months
- Fasting period before study: no
- Housing:
mice: 5 / cage
rats: 3-4 / cage
dogs: 2 / run
- Individual metabolism cages: yes
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: mice and rats 1 month each, dogs 3 months
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not specified (monitored during exposure only)
- Humidity (%): not specified (monitored during exposure only)
- Air changes (per hr): not specified (monitored during exposure only)
- Photoperiod (hrs dark / hrs light): 12h light / 12h dark
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS:
Exposures in 4.1 cubic meter stainless steel chambers under dynamic arflow. Total airflow through the chambers about 750 L/min. Vapors were generated by metering liquid tertiary amyl alcohol at a controlled rate into a heated (180°C) vaporization flask. Compressed air was used to sweep the vapors from the flask into the main chamber airflow where they were mixed and diluted with tempered air (about 22°C & 50% humidity) before entering the chamber. Control animals were not placed in a chamber but were kept in an animal room during the exposure period.
Temperature and relative humidity in the chambers and the animal room were recorded at least once each exposure day.
HOMOGENEITY AND STABILITY OF TEST MATERIAL:
- Stability of test item: measured prior to and following completion by flame ionisation-gas chromatography
- Homogeneity: not tested
CHAMBER CONCENTRATION.
- The analytical chamber concentration was monitored with a infrared spectrophotometer. The chamber concentration were analysed at least 3 times per day for each exposure level. - Duration and frequency of treatment / exposure:
- 59 to 61 days, for 6 hours per day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
nominal: 50; 225; 1000 ppm (0.18; 0.81; 3.6 mg/L)
measured: 50.5 +/- 1.9; 227.6 +/- 8.4 or 990.4 +/- 25.6 ppm
- No. of animals per sex per dose / concentration:
- 10 male and female CD-1 mice;
10 male and female Fischer 344 rats;
4 male beagle dogs.
4 additional male Fischer 344 rats and up to 18 male CD-1 mice, from the same shipment of animals, were added to each treatment group except control and used to define the clearance of 2-Methylbutan-2-ol from the plasma. - Control animals:
- yes
- Details on dosing and sampling:
- Blood samples were collected during the second month of the study following 5 consecutive daily 6 hour exposures.
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parametersopen allclose all
- Test no.:
- #1
- Toxicokinetic parameters:
- half-life 1st: 29 min (mouse, exposed to 1000 ppm)
- Test no.:
- #2
- Toxicokinetic parameters:
- half-life 1st: 47 min (rat, exposed to 50 ppm)
- Test no.:
- #3
- Toxicokinetic parameters:
- half-life 1st: 69 min (dog, exposed to 50 ppm)
Any other information on results incl. tables
The lowest plasma concentrations were found in the mouse and the highest concentrations were found in the dog. Half an hour after the end of the high concentration exposure the mean concentrations found in the plasma of mice, rats and dogs were 42 +/- 15, 98 +/- 5 and 341 +/- 189 µg/ml, respectively. The post-exposure plasma concentration time-profiles suggests that the observed differences in plasma concentrations were in part due to differences in the ability of these species to eliminate 2-methyl-2-butanol. Following the low concentration exposure, 2-methyl-2-butanol was cleared from the plasma of the rat and dog in a first-order manner (elimination not saturated). Following the high concentration exposure, 2-methyl-2-butanol was cleared from the plasma of mice in a first-order manner but was better described by assuming Michaelis-Menten or saturation kinetics in both rat and dog. The apparent half-life for the elimination of tertiary amyl alcohol in the mouse (t1/2 = 29 min) exposed to high concentration was less than in either the rat (t1/2 = 47 min) or dog (t1/2 = 69 min) exposed to low concentration.
Applicant's summary and conclusion
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