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EC number: 817-766-4 | CAS number: 91891-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 Sep - 11 Oct 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,1,2,3,3-pentafluoro-3-(heptafluoropropoxy)prop-1-ene
- EC Number:
- 817-766-4
- Cas Number:
- 91891-42-8
- Molecular formula:
- C6F12O
- IUPAC Name:
- 1,1,2,3,3-pentafluoro-3-(heptafluoropropoxy)prop-1-ene
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: MA-3-HO-ANL 1600356
- Expiration date of the lot/batch: 31 Aug 2020
- Purity test date: 05 Feb 2018
- Purity: 96.9%
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature container flushed with nitrogen
- Stability under test conditions: Yes
Other: ThOD calculated to be 0.25 mg O2/mg
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Remarks:
- predominantly domestic
- Details on inoculum:
- - Source of inoculum/activated sludge: Activated sludge from the 'Waterschap Aa en Maas' municipal sewage treatment plant ('s-Hertogenbosch, The Netherlands), receiving predominantly domestic waste.
- Storage conditions: Continuous aeration until use.
- Storage length: Not reported ("freshly obtained")
- Preparation of inoculum for exposure: Before use, the sludge was coarsely sieved (1 mm) and washed with mineral medium.
- Concentration of sludge: 3 g SS/L - Duration of test (contact time):
- 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 315 mg/L
- Based on:
- test mat.
- Initial conc.:
- 80 mg/L
- Based on:
- ThOD
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Mineral medium as per method TG301, water was purified by reverse osmosis and subsequently passed over activated carbon (Millipore, Bedford, MA, USA)
- Solubilising agent: none
- Test temperature: 22-23 °C
- pH: 7.6-7.7 on day 0, 7.7-8.7 on day 28
- pH adjusted: no
- Suspended solids concentration: 6 mg SS/L
- Continuous darkness: no
TEST SYSTEM
- Culturing apparatus: brown glass bottles with automatic respirometer head. Bottles held in a incubator with inductive stir motor
- Number of culture flasks/concentration: two
- Method used to create aerobic conditions: continuous stirring.
- Measuring equipment: Lovibond BD600-GLP manometric respirometry system. Decrease in air pressure due to respiration was measured by the respirometer heads and automatically converted into oxygen consumption (mg O2/L).
- Details of trap for CO2 and volatile organics if used: Two NaOH pellets held by a rubber gasket in each bottle
- Measurement frequency: Oxygen utilization was recorded on days 0, 4, 7, 11, 14, 18, 21, 25, and 28.
CONTROL AND BLANK SYSTEM
- Inoculum blank: duplicate
- Abiotic sterile control: none
- Procedural control: single
- Toxicity control: single, containing both reference and test substance at 80 mg ThOD/L
Reference substance
- Reference substance:
- acetic acid, sodium salt
- Remarks:
- 80 mg ThOD/L
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
- Remarks on result:
- other: Oxygen consumption less than in blanks
- Details on results:
- At all time points, oxygen consumption in test bottle A was less than in blank bottles (Table 1). At all time points after day zero, oxygen consumption in test bottle B was less than the measurement range of the equipment and was reported as zero before comparison with blank.
The reference substance was 68% degraded by day 7 and 78% degraded by day 14 (Table 2). Biodegradation in the toxicity control (Table 3) was 33% by day 7 and 35% by day 14. Therefore, MA-3 is not toxic to activated sludge
Any other information on results incl. tables
Table 1, Oxygen consumption (mg O2 g/L) in the blanks
Day |
Blank 1 |
Blank 2 |
Mean blank |
0 |
0 |
0 |
0 |
4 |
2 |
5 |
4 |
7 |
3 |
6 |
5 |
11 |
5 |
7 |
6 |
14 |
7 |
8 |
8 |
18 |
7 |
8 |
8 |
21 |
8 |
7 |
8 |
25 |
9 |
9 |
9 |
28 |
9 |
9 |
9 |
Table 2, Oxygen Consumption (mg O2/L) and Percentage Biodegradation in the Procedure Control
Day |
Mean blank |
Reference substance |
BOD |
%BOD |
0 |
0 |
1 |
1 |
1 |
4 |
4 |
59 |
56 |
69 |
7 |
5 |
68 |
64 |
79 |
11 |
6 |
74 |
68 |
85 |
14 |
8 |
78 |
71 |
88 |
18 |
8 |
79 |
72 |
89 |
21 |
8 |
80 |
73 |
91 |
25 |
9 |
82 |
73 |
91 |
28 |
9 |
83 |
74 |
93 |
Table 3 Oxygen Consumption (mg O2/L) and Percentage Biodegradation in the Toxicity Control
Day |
Mean blank |
Reference substance |
BOD |
%BOD |
0 |
0 |
0 |
0 |
0 |
4 |
4 |
50 |
47 |
29 |
7 |
5 |
57 |
53 |
33 |
11 |
6 |
60 |
54 |
34 |
14 |
8 |
64 |
57 |
35 |
18 |
8 |
57 |
50 |
31 |
21 |
8 |
54 |
47 |
29 |
25 |
9 |
57 |
48 |
30 |
28 |
9 |
59 |
50 |
31 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- DO uptake in blanks < 60 mg/L at end of test. Reference substance pass by day 14, <20% difference in biodeg for test material
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- MA-3 was 0% biodegraded in a 28-day OECD 301F test.
- Executive summary:
Ready biodegradability of MA-3 was studied in a test done according to OECD TG 301F. MA-3, sodium acetate (reference substance), or both chemicals (toxicity control) were introduced to respirometer bottles at 80 mg/L theoretical oxygen demand (ThOD). Bottles also contained mineral medium inoculated with activated sludge from a predominantly domestic source. Blank bottles containing only inoculated medium were also prepared. Oxygen utilization was monitored automatically at defined intervals. No degradation of MA-3 was measured after 28 days of incubation. The blank bottles had <60 mg/L oxygen utilization at end of test, and the reference substance was >60% degraded by day 14. The toxicity control exhibited sufficient degradation (>25% by 14 days) that MA-3 was considered to have not inhibited microbial actitivity in this test. Since MA-3 was not biodegraded in this test, it is not readily biodegradable.
This test was conducted under an internationally accepted guideline suitable for volatile chemicals, and was in accord with GLP criteria. Therefore, this study is reliable without restrictions.
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