Sodium periodate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23 April 2012 - 29 June 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

see below

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

yes

Remarks:

see below

Principles of method if other than guideline:

The standard methodology was not applicable to this test item due to the production of high saturation levels. For visual assessment, samples were required where saturation was not achieved in order to determine the point where saturation was achieved. Therefore, it was impractical to prepare samples at five times the saturation level as recommended in the guidelines.

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

8 - 9.3 other: % w/w

Temp.:

20 °C

pH:

3 - 4.9

Details on results:

PRELIMINARY TEST
The sample concentrations, observations and pH values of the solutions are shown in Table 3.
The preliminary water solubility was determined to be in the range 1.1 to 4.8 % w/w.
As this value was above 10^-2 g/L, the flask method was performed for the definitive test.
The somewhat low preliminary results were most likely due to these samples having not attained saturation.

DEFINITIVE TEST
The sample concentrations, observations and pH values of the solutions are shown in Table 4.
Overall, the water solubility was determined to be in the range 8.0 to 9.3 % w/w.

Table 1 Preliminary Test Results

Sample	Concentration (% w/w)	Observations	Solution pH
1	4.8	Clear, colourless solution, with small amount of undissolved white solid.	3.3
2	9.1	Clear, colourless solution, with some undissolved white solid.	3.5
3	16.6	Clear, colourless solution, with large amount of undissolved white solid.	3.3
4	1.1	Clear, colourless solution, with no excess test item.	5.1
5	0.14	Clear, colourless solution, with no excess test item.	6.2
6	0.011	Clear, colourless solution, with no excess test item.	6.6

 

Table 2 Definitive Test Results

Sample	Concentration (% w/w)	Observations	Solution pH
7	1.0	Clear, colourless solution, with no excess test item.	4.9
8	2.0	Clear, colourless solution, with no excess test item.	4.6
9	2.9	Clear, colourless solution, with no excess test item.	4.4
10	3.9	Clear, colourless solution, with no excess test item.	4.3
11	4.8	Clear, colourless solution, with no excess test item.	4.2
12	6.3	Clear, colourless solution, with no excess test item.	4.2
13	10.1	Clear, colourless solution, with excess test item.	3.4
14	14.1	As Sample 13, except much more excess test item than Sample 13.	3.0
15	18.4	As Sample 13, except much more excess test item than Sample 14.	3.1
16	22.0	As Sample 13, except much more excess test item than Sample 15.	3.1
17	7.1	Clear, colourless solution, with no excess test item.	4.1
18	8.0	Clear, colourless solution, with no excess test item.	3.9
19	9.3	Clear, colourless solution, with excess test item.	3.6

 

Conclusions:

Interpretation of results: very soluble (> 10 000 mg/L)
The water solubility of the test item has been determined to be in the range 8.0 to 9.3 % w/w of solution at 20.0 ± 0.5 °C.

Executive summary:

The evaluation of the water solubility of the test material was carried out using visual appraisal, based on the flask method, designed to be compatible with OECD Guideline 105 and EU Method A.6 under GLP conditions.

The water solubility of the test item has been determined to be in the range 8.0 to 9.3 % w/w of solution at 20.0 ± 0.5 °C.

Description of key information

The water solubility of the test material has been determined to be in the range 8.0 to 9.3 % w/w (equivalent to 80 to 93 g/L) of solution at 20.0 ± 0.5 °C.

Key value for chemical safety assessment

Water solubility:

80 g/L

at the temperature of:

20 °C

Additional information

The evaluation of the water solubility of the test material was carried out using visual appraisal, based on the flask method, designed to be compatible with OECD Guideline 105 and EU Method A.6 under GLP conditions. It was assigned a reliability score of 1 in accordance with the principles for assessing data quality as outlined in Klimisch et al (1997).

The water solubility of the test material has been determined to be in the range 8.0 to 9.3 % w/w (equivalent to 80 to 93 g/L) of solution at 20.0 ± 0.5 °C.