Registration Dossier
Registration Dossier
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EC number: 209-599-5 | CAS number: 587-26-8
Toxicity to soil microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Respiration rate: NOEC (28d) = 297.7 mg La/kg soil dw
Nitrate formation rate: NOEC (28d) = 283.2 mg La/kg soil dw
The tests with Lanthanum chloride hexahydrate has to be evaluated as a worst case scenario. It is to be expected, that the same study perfomed with Lanthanum carbonate will show no effects in this concentration range, since the Lanthanum ion of this test item is considerable lower bioavailable for the microorganisms.
Key value for chemical safety assessment
Additional information
No data are available for the toxicity to soil microorganisms with Lanthanum carbonate. Therefore data from the analogue source substance Lanthanum chloride hexahydrate were applied to cover the respective endpoint.
The long term effect of Lanthanum chloride hexahydrate on carbon transformation activity of soil microorganisms was investigated according to OECD 217 under GLP-conditions (Schulz 2010). Glucose-induced respiration rates were measured after 0, 7, 14 and 28 days incubation for 12 consecutive hours. The test item caused a maximum inhibition of 19.6% at 1514.2 mg LaCl3*6H2O/kg soil dw (highest concentration tested) 28 days after application. Only for this concentration a significant difference compared to the control was stated. The EC50 could not be calculated, but it can be concluded that the EC50 is higher than 1514.2 mg test item/kg soil dry weight (according to 595 mg La/kg soil dw), the highest concentration tested. The NOEC of the test item was calculated to be 757.10 mg LaCl3*6H2O/kg soil dry weight (according to 297.7 mg La/kg soil dw) after 28 days of exposure.
Furthermore, the long term effect of Lanthanum chloride hexahydrate on nitrogen transformation activity of soil microorganisms was tested according to OECD 216 under GLP-conditions (Lemnitzer 2010). After 0, 7, 14 and 28 days of incubation of soil, which was amended with powdered plant meal at the beginning of the test, samples of treated and control soils are extracted and quantities of nitrate in the extracts is determined. After 28 days the treatment with 1441 mg LaCl3*6H20 /kg soil dry weight (according to 567 mg La/kg soil dw) showed an inhibition of 18.5 %. Only for this concentration a significant difference compared to the control was stated. The EC50 could not be calculated, but it can be concluded that the EC50 is higher than 1441 mg LaCl3*6H20/kg soil dw (according to 566.5 mg La/kg soil dw), the highest concentration tested. The NOEC of the test item derived from the variance analysis was 720 mg LaCl3*6H2O/kg soil dw (according to 283.2 mg La/kg soil dw) after 28 days of exposure.
Since Lanthanum chloride has a high water solubility (861 g/L) compared to the water solubility of Lanthanum carbonate (1.24 mg/L), the test conditions has to be evaluated as a worst case scenario. It is to be expected, that the same study perfomed with Lanthanum carbonate will show no effects in this concentration range, since the Lanthanum ion of this test item is considerable lower bioavailable for the microorganisms.
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