Dilanthanum tricarbonate

Density

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

16 Feb 2009

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP-Guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

yes

Remarks:

The temperature during the determination was not constant to ± 0.5 °C

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Deviations:

yes

Remarks:

The temperature during the determination was not constant to ± 0.5 °C

GLP compliance:

yes (incl. QA statement)

Remarks:

Landesamt für Umwelt, Wasserwirtschaft und Gewerbeaufsicht, Kaiser-Friedrich-Str. 7, 55116 Mainz, Germany

Type of method:

pycnometer method

Remarks:

following Guy-Lussac

Type:

relative density

Density:

3.48 other: unitless

Temp.:

19.6 °C

The density of the test item Dilanthanum tricarbonate was calculated as

3.4767 ± 0.0012 g/cm³at a temperature range of 18.8 - 20.1 °C.

Precision of the value is given as maximal error of determination.

The standard deviation of the two values is higher than the maximal error, indicating that the error of the duplicate determination was higher than the calculated value for a single determination. The measured values show good correlation (RSD 0.15%), therefore, the study is considered valid.

The temperature during the determination was not constant to ± 0.5 ^oC. As the test item consists of a solid, the change in density is considered as uncritical.

Measured values:

Mass in g	M1	M2	M3	M4	M5
First determination	42.9365	93.0217	93.0269	57.9288	103.7089
Second determination	42.9399	93.0120	93.0280	58.6151	104.2055

Density of replacement liquid at first and second determination: 0.9985 and 0.9986 g/cm3

Density calculation (single determination):

Determination	Density (g/cm3)	Error of Determination (g/cm3)
1	3.4731	0.0012
2	3.4804	0.0011

Density calculation (mean values):

	Value	Standard Deviation
Volume of Pycnometer (cm3)	50.16	0.0058
Density of test item (g/cm3)	3.4767	0.0052
Relative Density of test item	3.4767	0.0052

Reference 2

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

07 Nov - 09 Nov 2005

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP-Guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

Swiss federal Office of public health, Bern, Switzerland

Type of method:

air comparison pycnometer (for solids)

Type:

density

Density:

2.02 g/cm³

Temp.:

20.3 °C

Type:

relative density

Density:

2.02

Temp.:

20.3 °C

Determination of the density of Lanthanum carbonate:

Sample n°.	Sample Weight [g]	Measurement	p1 (sample) [psi]	p2 (sample) [psi]	V (sample) [cm^3]	Density   [g/cm^3]
1	47.396	1 2 3	15.506 15.585 15.530	5.303 5.330 5.311	23.380 23.380 23.373	2.027 2.027 2.028
2	48.863	1 2 3	15.579 15.528 15.540	5.350 5.332 5.339	24.211 24.193 24.302	2.018 2.020 2.011
Mean :						2.022
Standard deviation +/- [g/cm^3]						0.007

Description of key information

Relative density: 3.48 at 19.6 °C

Key value for chemical safety assessment

Relative density at 20C:

3.48

Additional information

The density was analysed according to OECD 109 (Paulus 2009). With a pycnometer following Gay-Lussac a density of 3.48 g/cm³ at 19.6 °C was stated.