Registration Dossier
Registration Dossier
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EC number: 200-662-2 | CAS number: 67-64-1
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
According to several reliable studies, acetone is readily biodegradable.
In a modified OECD 301B screening test acetone was biodegraded to 90.0 ± 2.2 % after 28 days. The 10 days window was met.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
According to several reliable studies, acetone is readily biodegradable.
In a modified OECD 301B screening test acetone was biodegraded to 90.9 ± 2.2 % after 28 days. The 10 days window was met. In a BOD-test according to APHA Standard methods No. 219 (1971) acetone was degraded to 84% based on ThOD in 5 days. In two further BOD-tests biodegradation of acetone yielded 76% after 10 days (84% after 20 days) and 81% after 20 days, respectively. There is one study available for sea water. In a BOD-test acetone was biodegraded in synthetic salt water by a sea water adapted inoculum to 76% in 20 days. The pass level of 60 % was barely failed. This indicates that biodegradation of acetone may be somewhat slower in sea water, but not significantly.
Acetone is biodegradable under anaerobic conditions by adapted microorganisms. After a lag phase of 5 days complete biodegradation was observed within 4 days by microorganisms previously cross-adaptedwith acetate.
Another study confirms that acetone is biodegradable under sulphate-reducing, anaerobic conditions by Desulfococcus biacutus, which is adapted to acetone. Acetone is channelled into the intermediate metabolism of the microorganism via a C4-species (acetoacetyl-CoA) and subsequent cleavage to acetyl-CoA and oxidation to CO2. Carbon dioxide is needed for the acetone oxidation via this mechanism. Degradation of acetone was found to be 74.3 - 95.4 %
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