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EC number: 212-603-8 | CAS number: 831-52-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- OPINION ON Picramic acid and sodium picramate COLIPA n° B28
- Author:
- Scientific Committee on Consumer Safety,
- Year:
- 2 012
- Bibliographic source:
- Scientific Committee on Consumer Safety, (SCCS) 18 September 2012
- Reference Type:
- publication
- Title:
- Final Report on the Safety Assessment of Sodium Picramate
- Author:
- Cosmetic Ingredient Review Panel
- Year:
- 1 992
- Bibliographic source:
- JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY; Volume 11, Number 4,1992
- Reference Type:
- publication
- Title:
- Amended Safety Assessment of Sodium Picramate and Picramic Acid
- Author:
- Lillian C. Becker, Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, JamesG.Marks Jr, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, and F. Alan Andersen
- Year:
- 2 009
- Bibliographic source:
- International Journal of Toxicology; 28(Suppl 3); 205S-216S, 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the eye irritation potential of the test chemical in albino rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium 2-amino-4,6-dinitrophenoxide
- EC Number:
- 212-603-8
- EC Name:
- Sodium 2-amino-4,6-dinitrophenoxide
- Cas Number:
- 831-52-7
- Molecular formula:
- C6H5N3O5.Na
- IUPAC Name:
- sodium 2-amino-4,6-dinitrophenoxide
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data available
Test system
- Vehicle:
- other: 2.5% aqueous test chemical (buffered to pH 7)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1ml of 2.5% aqueous test chemical (buffered to pH 7)
- Duration of treatment / exposure:
- the lids were held together for 1 second
- Observation period (in vivo):
- 24, 48, and 72 hours
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: At 10 seconds post-instillation, the eyes were rinsed with 20 mL of distilled water
Observation period:Reactions were scored at 24, 48, and 72 hours post-instillation.
TOOL USED TO ASSESS SCORE: hand-slit lamp / biomicroscope / fluorescein: no data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Mild conjunctival inflammation was observed in each animal.
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- Mild conjunctival inflammation was observed in each animal. It can be considered that 2.5% aqueous test chemical solution (buffered to pH 7) was not an ocular irritant
- Executive summary:
The eye irritation potential of the test chemical was assessed in albino rabbits.
0.1 ml of 2.5% aqueous test chemical (buffered to pH 7) was instilled into the eyes of albino rabbits (N = 3) and the lids were held together for 1 second. At 10 seconds post-instillation, the eyes were rinsed with 20 mL of distilled water. Untreated eyes served as controls. Reactions were scored at 24, 48, and 72 hours post-instillation.
Mild conjunctival inflammation was observed in each animal. It can be considered that 2.5% aqueous test chemical solution (buffered to pH 7) was not an ocular irritant
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