Registration Dossier
Registration Dossier
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EC number: 431-060-1 | CAS number: 153719-38-1
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Hydrolysis of CA 2343 at approximately 500 mg/L (exact concentrations are known) was studied in a preliminary test in the dark at 50ºC in sterile aqueous buffered solutions at pH 3.8 (citrate buffer), pH 7 (phosphate buffer) and pH 9 (borax buffer) for 5 days.
Samples were analysed at 0h, 2 -4h, 2d, and 5d after taking aliquots from the hydrolysis solution by HPLC using external standard calibration.
After five days at 50 °C less than 10 % of the test substance had hydrolysed at pH 3.8. Therefore, in accordance with the test methods used, thehalf-life (lives)/DT50 (50% decline times)of the test substance may be estimated from the preliminary test to be > 1 year at 25 °C and 20 °C for pH 3.8.
Further testing was conducted for pH 7.0 at temperatures of 50, 70 and 80 °C and for pH 9.0 at 40 and 50 °C in order to determine the half-life times by extrapolation of the Arrhenius fit:
Half-life times (t1/2)
Buffer solution 20 °C 25 °C
pH 7.0 3800 days 1500 days
pH 9.0 36 days 17 days
Key value for chemical safety assessment
Additional information
Guideline Test Type |
Species |
Half life |
Reference |
Reliability
|
EU C.7 |
Not applicable |
pH 3.8 (20/25 °C) > 1 yr pH 7 (20 °C): 3800 d pH 7 (25 °C): 1500 d pH 9 (20 °C): 36 d pH 9 (25 °C): 17 d |
Schulz, J., Novartis, 1999 |
Reliable without restrictions |
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