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EC number: 419-690-3 | CAS number: 88020-55-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Feb 3rd - Mar 3rd, 1987
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: other guideline : 28 days of tube feeding according the EPA (40 CFR parts 160 and 792)
- Deviations:
- not specified
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 419-690-3
- EC Name:
- -
- Cas Number:
- 88020-55-7
- Molecular formula:
- [(C12H25)3NH]4Mo8O26
- IUPAC Name:
- tridodecylamine hydrate molybdenum
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- 7 days/week
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
10 mg/kg/day
Basis:
no data
- Remarks:
- Doses / Concentrations:
50 mg/kg/day
Basis:
no data
- Remarks:
- Doses / Concentrations:
250 mg/kg/day
Basis:
no data
- No. of animals per sex per dose:
- Male : 5 animals at 0 mg/kg bw/day
Male : 5 animals at 10 mg/kg bw/day
Male : 5 animals at 50 mg/kg bw/day
Male : 5 animals at 250 mg/kg bw/day
Female : 5 animals at 0 mg/kg bw/day
Female : 5 animals at 10 mg/kg bw/day
Female : 5 animals at 50 mg/kg bw/day
Female : 5 animals at 250 mg/kg bw/day - Control animals:
- yes, concurrent vehicle
Results and discussion
Results of examinations
- Details on results:
- Clinical observations :
no mortality linked to the substance ; accidental deaths occured in the test group and in the treated groups for 10 and 250 mg/kg/j.
No clinical signs, except those resulting from tube feeding mistakes.
Reduction of food consumption (males, week 2) and of corporal weight (males, week 2,3, and 4) : group 4
Laboratory findings :
statistically no significant difference of the different haematological parameters.
On biological plan, increase of creatinine for the males of the group 4 ; we observed for few males from group 3, an increase of ASAT, and for males from group 3&4, of ALAT.
No other significant anomaly on toxicological plan.
Effects on organs : for the males from the group4 :
- increase of the brain relative weight, and surrenals,
- decrease of liver absolute weight.
Regarding the histological examination, moderate damage of the epithelium of the renal tubules (cortical tubular hyperplasia) for the males and 4 females from the group 4.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 50 mg/kg bw/day (actual dose received)
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Laboratory observations:
A slight increase in blood urea nitrogen and aspartate and alanine transferases at 250 mg/kg/day.
Effects on bodies :
Mild to marked regenerative hyperplasia of the epithelium of the cortical tubules of the kidney at 250 mg/kg/day
Applicant's summary and conclusion
- Conclusions:
- NOAEL = 50 mg/kg bw/day
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