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EC number: 406-260-5 | CAS number: 58834-75-6 BTN; VPO CATALYST
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Long-term toxicity to fish: NOEC = 0.041 mg/L
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.041 mg/L
Additional information
Long-term toxicity has been investigated in the American flagfish. Exposure commenced on one week old larvae and continued for 96 days. Fish were continuously exposed to vanadium concentrations of 0, 0.041, 0.17, 0.48 and 1.5mg/L. Mortality, growth, and abnormalities were assessed following 28, 70 and 96 days of exposure. Daily counts of number of eggs laid were made from Day 71 to 95 of exposure. Fertility and hatchability of eggs was assessed on eggs collected on the first four successive days of spawning that yielded 20 or more eggs. Mortality, growth, and abnormalities of the 2nd generation were assessed during the 30 days following hatching.
Sub-acute lethality to the fry was the most important finding. If fish survived the first month of exposure, they suffered few sub-lethal effects during the remaining period of the study. This indicates that vanadium is not acting as a cumulative poison. If accumulation had been occurring the first generation of fish might have been expected to sicken or die as they accumulated the metal during their lifetime, but there was no indication of this. For example, the final size and spawning performance of survivors in 1.5 mg/L of vanadium was not different from controls, although that concentration had killed 73% of the fry. Dry weight of the 2nd generation fish revealed adverse effects of exposure at exposure concentrations of 0.17 mg/L and above when compared to controls.
At the lowest concentration investigated, 0.041 mg/L, there were no adverse sub-lethal effects during the study. The mortality observed in second-generation larvae exposed at 0.041 mg/L was regarded by the authors to be anomalous in view of the much lower mortality at the next highest concentration and the lack of a concentration/effect relationship. Vanadium at 0.041 mg/L was therefore regarded as the NOEC with a threshold for chronic or sub-lethal responses between 0.041 and 0.17 mg/L.
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