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EC number: 414-780-9 | CAS number: 38585-74-9 A-87440.0; A-87440.00
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 4 July - 7 Aug, 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: done under OECD method and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 5-thiazolylmethanol
- EC Number:
- 414-780-9
- EC Name:
- 5-thiazolylmethanol
- Cas Number:
- 38585-74-9
- Molecular formula:
- C4H5NOS
- IUPAC Name:
- (1,3-thiazol-5-yl)methanol
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- a) Inoculated Nutrient Medium
b) 4mg/l test substance
c) 3mg/l sodium benzoate (C6H5.COONa)
d) 4mg/l test substance + 3mg/l sodium benzoate
Inoculation of stock nutrient medium with activated sludge filtrate at the rate of 1ml inoculum/l performed immediately prior to preparation of the above series. - Duration of test (contact time):
- 28 d
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Remarks:
- dissolved oxygen concentration
- Details on study design:
- 280ml darkened glass BOD bottles incubated in a water bath at 21±1°C and analysed for dissolved oxygen at 0, 4, 7, 11, 14, 18, 21, 25 and 28 days.
The test substance is considered to have an inhibitory effect on the bacteria if the oxygen demand in series 'd' (above) is 25% less than the sum of oxygen demand in series'b' and 'c' at 14 days.
Reference substance
- Reference substance:
- other: Sodium benzoate
Results and discussion
- Preliminary study:
- A-87440.0 may not be termed as readily biodegadeable.
There was no evidence of inhibitory effects.
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 20
- Sampling time:
- 28 d
- Details on results:
- Cultures containing both test and standard substances combined showed an oxygen depletion value 47% higher than that anticipated on the basis of results from separate cultures at day 14. Therefore, the test substance is not considered to have had an inhibitory effect on sewage bacteria under the test conditions.Points of degradation plot (test substance):
6 % degradation after 4 d
8 % degradation after 7 d
7 % degradation after 11 d
6 % degradation after 14 d
3 % degradation after 18 d
12 % degradation after 21 d
12 % degradation after 25 d
20 % degradation after 28 d
BOD5 / COD results
- Results with reference substance:
- Sodium benzoate attained 72% biodegradation within 28 days.
Points of degradation plot (reference substance):
70 % degradation after 4 d
70 % degradation after 7 d
72 % degradation after 11 d
65 % degradation after 14 d
67 % degradation after 18 d
71 % degradation after 21 d
64 % degradation after 25 d
72 % degradation after 28 d
Any other information on results incl. tables
As nitrogen was present to a significant extent, at day 28, nitrite and nitrate analyses were performed on the test solutions in order to determine the extent of nitrification. The amount of oxygen uptake due to nitrification processes was not considered to be significant at 0.082 mgO2/l cf. total O2 depletion of 1.225 mgO2/l. Therefore, the Theoretical Oxygen Demand (NH4) of A-87440.0 was used to determine the extent of carbonaceous biodegredation
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: not readily biodegradable
- Conclusions:
- The test material attained 20% degradation after 28 days and therefore cannot be considered to be readily biodegradable under the test conditions.
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