Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 470-470-3 | CAS number: 9022-75-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 3.6 µg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 8.75 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.36 µg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 3.16 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 10.41 mg/kg sediment dw
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 1.041 mg/kg sediment dw
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 4.05 mg/kg soil dw
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 5 mg/kg food
- Assessment factor:
- 300
Additional information
Conclusion on classification
The substance exhibits surface active properties (non-ionic) and thus meets the criterion for substances difficult to test. The surface activity has been experimentally verified by determination of surface tension (26.6 mN/m, solution 1 g/L). It is expected that the substance can form emulsions in aquatic testing making assessment of bioavailability difficult to ascertain. The critical micelle concentration has been determined to 7.55 µg/mL at 20°C. One of the main difficulty with testing the substance was the maintenance of exposure concentrations. Generally, concentrations were recovered in applications solutions but deviated more than 80% of nominal values in test solutions either in the course of experiment or at the moment of medium renewal/end of experiment. Thus, effect concentrations were expressed as geometric means.
-Short-term toxicity
Fish Acute (2004): 96h-LC50 = 1.02 mg/L (95% CL: 0.48 -2.2 mg/L) based on meas. geom.
Fish Acute (2003): 96h-LC50 = 1.61 mg/L (95% CL: 1.32 -3.01 mg/L) based on meas. geom.
Daphnia Acute (2004): 48h-EC50 = 1.1 mg/L (95%CL: N/A) based on meas. geom.
Daphnia Acute (2003): 48h-EC50 = 0.875 mg/L (95% CL: 0.5 -1.40 mg/L) based on meas. geom.
Algae (2003): 72h-ErC50 = 1.11 mg/L (95% CL: 0.821 -1.64 mg/L) based on meas. geom. 72h-NOECr = 0.5 mg/L
Algae (2004): 72h-ErC50 = 2.1 mg/L (95% CL: 0.34 -4.9 mg/L) based on meas. geom.; 72h-NOECr = 0.62 mg/L
-Long term toxicity
Fish Chronic (2011): 30d-NOEC = 0.086 mg/L (no significant difference with vehicle control) based on meas.
TWA Daphnia Chronic (2004): 21d-NOEC = 0.036 mg/L based on meas. TWA
-Evidence of rapid degradation in aquatic system is provided in the dataset
OECD Guideline 301B: %Biodeg. = 88% (Day 28) based on CO2 evolution. The 10 -day window started on Day 5 and the test substance attained 69% of biodegradation on Day 15.
-Bioaccumulation
No fish bioconcentration factor is available. Log kow for main constituent equal to 3.757 (est.).
CLP Classification proposal
It is proposed to compare CHIMEXANE dataset to CLP environmental criteria laid down in CLP Regulation (including 2nd Adaptation to Technical Progress, Com Reg No 286/2011).
Acute Cat 1 Reasoning: lowest E(L)C50 below 1 mg/L but > 0.1 mg/L. M-Factor of 1.
Chronic Cat 2 Reasoning: readily biodegradable substance, lowest toxicity value between 0.01 and 0.1 mg/L. M-Factor not applicable.
DSD Classification proposal
N; R50/53 Reasoning: lowest E(L)C50 below 1 mg/L, readily biodegradable but log Kow of main constituent > 3.0.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.