Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 929-442-0 | CAS number: 1040871-35-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute oral toxicity of the test substance Reaction mass of iso-tridecyl 3-mercaptopropionate and iso-dodecyl 3-mercaptopropionate following a single oral administration was determined according to the OECD guideline 423 and EU Method B.1. The test animal species and strain were the SpragueDawley CD strain rat. The method used was according to the "Acute toxic Class Method”.
No data is available concerning the acute dermal and the acute inhalatory toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-09-08 to 1998-10-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- ; starting dose was not one of the four fixed levels given in the current guidelines
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- ; starting dose was not one of the four fixed levels given in the current guidelines
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Species:
- rat
- Strain:
- other: Sprague-Dawley Crl :CD (SD) IGS BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles RIver (UK) Ltd, Margate, Kent, UK
- Age at study initiation: 8-12 weeks
- Weight at study initiation: 203-227g (males), 204-217g (female)
- Fasting period before study: overnight fast before dosing
- Housing: in groups of up to three by sex in solid-floor polypropylene cages furnished with woodflakes
- Diet (e.g. ad libitum): free access to "Rat and Mouse Expanded Diet No. 1"; special diets services limited; Witham; Essex; UK
- Water (e.g. ad libitum): free access
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-25°C
- Humidity (%): 47-64%
- Air changes (per hr): approximately fifteen
- Photoperiod (hrs dark / hrs light): 12h / 12h
IN-LIFE DATES: From: 2008-09-08 To: 2008-10-12 - Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20, 50 and 200mg/mL
- Amount of vehicle (if gavage): 10mL/kg
- Justification for choice of vehicle: test substance did not dissolve in distilled water or other aqueous vehicles
MAXIMUM DOSE VOLUME APPLIED: 10mL/kg
DOSAGE PREPARATION (if unusual): formulations were dosed within 42 minutes of preperation
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: 200mg/kg was suggested - Doses:
- 200, 500 and 2000mg/kg bw
- No. of animals per sex per dose:
- 3 males and three females for dose group 200 and 500mg/kg bw;
3 females for dose group 2000mg/kg bw - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 0.5, 1, 2 and 4h after dosing and subsequently once daily (signs of toxicity); prior to dosing and 7 and 14 days after treatment (weighing)
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight and necropsy - Statistics:
- not applicable
- Preliminary study:
- none
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 500 - < 2 000 mg/kg bw
- Mortality:
- No mortalities were noted at 200 or 500 mg/kg bw. Two animals treated with 2000 mg/kg were found dead during the day of dosing and the remaining animal treated with 2000 mg/kg was found dead one day after dosing.
- Clinical signs:
- other: Common signs of systemic toxicity noted, prior to death, in animals treated with 2000mg/kg were hunched posture, lethargy, decreased respiratory rate, laboured respiration, prostation, tonic convulsions, increased salivation with incidents of pallor of th
- Gross pathology:
- Abnormalities noted at necropsy of animals that died during the study were haemorrhagic lungs, dark liver and dark kidneys. No abnormalities were noted at necropsy of animals that were killed at the end of the study.
- Other findings:
- none
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral LD50 of the test material was determined to be greater than 500mg/kg but less than 2000mg/kg bw.
- Executive summary:
A study was performed to assess the acute oral toxicity of the test material following a single oral administration to the SpragueDawley CD strain rate. The method used was according to the "Acute toxic Class Method”.
Using all available information, 200mg/kg bodyweight was selected as the starting dose. A group of three fasted females was treated with the starting dose of 200mg/kg. This was followed by a group of three fasted males at the same dose level. Based on the results from this dose level a further group of fasted females was treated at a dose level of 2000mg/kg bodyweight and a further group of fasted males and females was treated at a dose leve of 500mg/kg bw. Dosing was performed sequentially.The test material was administered orally as a solution in arachis oil. Clinical observations were performed 0.5 1, 2 and 4 hours after dosing and then once daily for up to fourteen days. Bodyweights were recorded on Day 0 (day of dosing) and on Days 7 and 14, or at death. At the end of the observation period the surviving animals were killed by cervical dislocation. All animals were subjected to gross necropsy.
Two females treated with 2000mg/kg were found dead during the day of dosing and the remaining female treated with 2000mg/kg was found dead one day after dosing. Clinical signs of toxicity noted, prior to death, in animals treated with 2000mg/kg were hunched posture, lethargy, decreased respiratory rate, laboured respiration, prostration, ataxia, increased salivation, tonic convulsions and pallor of the extremities. Clinical signs of toxicity noted in animals treated with 500mg/kg were hunched posture, up to one day after dosing. No clinical signs of toxicity were noted in animals treated with 200mg/kg. The surviving animals showed expected gains in bodyweight over the study period.
Abnormalities noted at necropsy of animals that died during the study were haemorrhagic lungs, dark liver and dark kidneys. No abnormalities were noted at necropsy of animals that were killed at the end of the study.Mortalities were noted at a dose level of 2000mg/kg bodyweight. No mortalities were noted in animals treated with 200 or 500mg/kg bw.
The acute oral LD50 of the test material was determined to be greater than 500mg/kg but less than 2000mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 500 - < 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The acute oral LD50 of the test substance Reaction mass of iso-tridecyl 3-mercaptopropionate and iso-dodecyl 3-mercaptopropionate was determined to be greater than 500 mg/kg but less than 2000 mg/kg bw.
Justification for classification or non-classification
Based on the available data, iC13MP s classifies as Acute Tox 4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.