Registration Dossier
Registration Dossier
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EC number: 233-046-7 | CAS number: 10025-87-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- No information
- Year:
- 1 978
- Bibliographic source:
- TSCATS: OTS 0534840, Doc. ID. 88-920000388, Younger Labs.|for Monsanto Co., 9-11-78
Materials and methods
- Principles of method if other than guideline:
- other: no data
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- phosphorus oxychloride
- IUPAC Name:
- phosphorus oxychloride
- Details on test material:
- no data on purity of the compound
Constituent 1
Test animals
- Species:
- rabbit
- Sex:
- male/female
Administration / exposure
- Vehicle:
- other: undiluted
- Details on dermal exposure:
- Male and female New Zealand albino rabbits were applied the undiluted test substance for 24 hours and were observed for 14 days.
- Duration of exposure:
- 24 hours
- Doses:
- The test substance was applied at dose levels of 398 mg/kg, 631 mg/kg, 1000 mg/kg, and 1580 mg/kg.
- No. of animals per sex per dose:
- 398 mg/kg (1 male), 631 mg/kg (1 female), 1000 mg/kg (1 male, 1 female), and 1580 mg/kg (1 male)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 631 - 1 000 mg/kg bw
- Mortality:
- The male given 1580 mg/kg and the female given 1000 mg/kg died 2 and 4 days after dosing, respectively.
- Clinical signs:
- other: Signs of intoxication included weight loss, increasing weakness, and collapse.
- Gross pathology:
- Gross autopsy revealed lung and liver hyperemia, enlarged gall bladder, kidney discolouration, and gastro-intestinal inflammation. Viscera of the surviving animals appeared normal after 14 days.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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