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EC number: 238-063-3 | CAS number: 14206-62-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
BONA free acid was tested for repeated dose toxicity (OECD SISDS SIAM 19). The substance caused an increase in bilirubin in both sexes, a slight increase in liver weight in females of the high dose group and adrenal necroses in two females of the mid and high dose group, repectively.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 12 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
Reasons for read across
The test item is the sodium salt of a naphthoic acid. In an acidic enviroment (e.g. stomach), the salt complex becomes dissociated into the sodium cation and the organic acid. Therefore, it is acceptable to derive repeated dose toxicity data from the free acid.
Statement of repeated dose toxicity (OECD SIDS SIAM 19)
In a 28 day gavage study in Wistar rats ( 0, 12, 60, 300 mg/kg bw/day), performed in accordance with the old OECD TG 407 (1981), 3-hydroxy-2-naphthoic acid had no influence on body weights, food consumption and behaviour of the animals. In the high-dose group, an increased water consumption was observed during the first two study weeks; at the end of the study, the serum phosphate levels were significantly decreased and bilirubin levels were increased in serum and urine in both sexes. Females showed a slight, but statistically significant increase in liver weights at 300 mg/kg bw/day (without histopathological correlate)(no further details available). At histopathology, one female of the high-dose and one female of the mid-dose group showed adrenal necroses. NOEL: 60 mg/kg bw/day (males), 12 mg/kg bw/day (females).
Poorly documented studies in rats involving repeated administration by the inhalation route gave indications of an effect on the kidneys (kidney necroses were reported after 10-days inhalation of 100 mg/m3)(Prosolenko NV and Vasilenko NM, 1979).
Conclusion
After repeated administration to rats by the oral route for 28 days, there were indications of a possible effect on the adrenals in females at dose levels of 60 mg/kg bw/day and above. The only effects observed in males were a significantly reduced serum phosphate level and increased levels of bilirubin in serum and urine at a dose level of 300 mg/kg bw/day. The same findings, and, in
addition, increased liver weights were reported for females at 300 mg/kg bw/day. NOEL (male): 60 mg/kg bw/day; NOEL (female): 12 mg/kg bw/day.
Poorly documented studies in rats involving repeated administration by the inhalation route gave indications of an effect on the kidneys (kidney necroses were reported after 10-days inhalation of 100 mg/m3)
Justification for classification or non-classification
The data given above are from secondary sources and not suitable for a statement of classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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