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Diss Factsheets
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EC number: 700-464-0 | CAS number: 99591-74-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The carbon dioxide (CO2) evolution test (modified Sturm test) was performed with MMDS.
The test revealed 48 and 60% (mean of 54%) biodegradation of MMDS. As biodegradation of MMDS of at least 60% was not reached within a 10-day window, the criterion for ready biodegradability was not met. In the toxicity control, MMDS was found not to inhibit microbial activity.
Although the substance MMDS was tested in this study, one can assume that, based on the rapid hydrolysis, the biodegradation is actually the biodegradation of the hydrolysis products MDSA and formaldehyde.
QSAR calculations were applied to both hydrolysis products: formaldehyde showed ready biodegradability and for MDSA, no conclusion on biodegradability was possible as all models did not reveal the same results. However, from the biodegradation test of MMDS one can estimate the contribution of each of the hydrolysis products to the biodegradation. The biodegradation test on MMDS revealed 54% biodegradation based on CO2 evolution. Considering that additionally about 30-40% is incorporated into biomass (REACH Guidance Chapter R.7.9.4.1), this result of 54% indicates a nearly complete ultimate degradation of MMDS. Considering that MMDS hydrolyses into 2 molecules with equal carbon mass, this also implies that both hydrolysis products contribute significantly to the biodegradation.
For the CSA, the hydrolysis products will be considered instead of the substance MMDS. It is deemed acceptable to use the value ready biodegradable for formaldehyde. For MDSA, although the above considerations imply that both hydrolysis products biodegrade significantly, the QSAR models did not lead to a definite conclusion. As no conclusion could be reached, it was decided to apply the worst case result and consider MDSA as not readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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