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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline or GLP defined.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1985

Materials and methods

Principles of method if other than guideline:
other: acute oral gavage toxicity study in cats; the animals received 10 and 50 mg/kg bw of test substance
GLP compliance:
not specified
Test type:
other: Acute oral toxicity

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-dichloro-4-nitrobenzene
EC Number:
210-248-3
EC Name:
1,3-dichloro-4-nitrobenzene
Cas Number:
611-06-3
Molecular formula:
C6H3Cl2NO2
IUPAC Name:
2,4-dichloro-1-nitrobenzene

Test animals

Species:
cat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Lutrol
Doses:
10; 50 mg/kg bw
No. of animals per sex per dose:
1
Control animals:
not specified

Results and discussion

Effect levels
Remarks on result:
other: Up to 8 hours after application a loss of appetite was observed. No other symptoms were noticed. Met-hemoglobin concentration and the number of HEINZ-Innenkörper were not increased after 3, 7, and 24 hours

Any other information on results incl. tables

Results of the hematological analysis:

             Blood-parameter after         
 Dose (mg/kg)  0 h  3 h  7 h  24 h  30 h  Animal no:  Sex:
 10   Met-hb. (%)  2 2  3 1  -   5422  m
 50   Met-hb. (%)  1 2  4  1  -   5916  m
 10  HK (%)  6  11  13  10  -  5422  m
 50  HK (%)  3  3  4  5  -  5916  m

m= male

- = not measured

Applicant's summary and conclusion

Executive summary:

In an acute oral gavage toxicity study in cats the animals received 10 and 50 mg/kg bw of test substance in a single dose.

The met-hemoglobin concentration and the number of HEINZ-Innenkörper were not increased after 3, 7, and 24 hours.

Up to 8 hours after application a loss of appetite was observed. No other symptoms were noticed.