Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information

Data source

Reference
Reference Type:
secondary source
Title:
No information
Bibliographic source:
ECHA database; http://apps.echa.europa.eu/registered/data/dossiers/DISS-9d91195a-65f3-618d-e044-00144f67d249/DISS-9d91195a-65f3-618d-e044-00144f67d249_DISS-9d91195a-65f3-618d-e044-00144f67d249.html

Materials and methods

Type of study / information:
Inhalation experiment in human subjects
Principles of method if other than guideline:
Exposure in a 1200 cubic foot gas cabinet of an average number of 10 people of both sexes to a given concentration of solvent vapour for a period of 3 to 5 minutes.

Results and discussion

Results:
Butanone produced slight nose and throat irritation at 100 ppm. Mild eye irritation appeared in some subjects at 200 ppm. 300 ppm was conclusively rejected.

Applicant's summary and conclusion