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EC number: 932-389-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- three-generation reproductive toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- March 1981- March 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- This study was conducted with a method equivalent to the OECD 416 (2001): OPPTS 870.3800 (1998): 2004/73/EC B.35 (2004) Guidelines and following the principlesand practices of Good laboratory Practice. A Quality Assurance statement is included in the report. None of the deviations from the current regulatory guideline are considered to compromise the scientific validity of the study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 416 (Two-Generation Reproduction Toxicity Study)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.3800 (Reproduction and Fertility Effects)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.35 (Two-Generation Reproduction Toxicity Test)
- Principles of method if other than guideline:
- The following deviations from the current guidelines were noted: Oestrus cycle length and normality were not evaluated by vaginal smears prior to mating. Daily dosing of the parental animals began when they were approx 4 weeks of age but continued for at least 12 weeks prior to the mating period. The animals were only observed once daily for morbidity and mortality. Food consumption was not measured during gestation. No organ weights were recorded. Testes and epididymides were not used for enumeration of homogenisation-resistant spermatids and cauda epididymides sperm reserves. Sperm motility and sperm morphology were not evaluated. Live pups were counted and litters weighed (pup weights) on the morning after birth and on days 4 and 7 and 21 of lactation and at termination. Timing of sexual maturation was not recorded. Anogenital distance was not recorded. Functional investigations of offspring were not assessed. At the time of necropsy, a vaginal smear was not taken to determine the stage of the oestrus cycle. The uteri of all primiparous females were not examined for the presence and number of implantation sites. A quantitative evaluation of primordial follicles was not conducted for F1 females. A copy of the study protocol is not included in the report. None of these deviations from the current regulatory guideline are considered to compromise the scientific validity of the study.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate
- EC Number:
- 932-389-6
- Molecular formula:
- C23H19ClF3NO3
- IUPAC Name:
- Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate
Constituent 1
Results and discussion
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The study is considered to be reliable with restrictions. The results are sufficiently detailed and unambiguous as to be adequate for risk assessment, classification and labeling.
- Executive summary:
In a three-generation reproduction study, cyhalothrin was administered to Alpk/AP, (Wistar derived) rats in the diet at dose levels of 0, 10, 30 or 100 ppm (males: 0, 0.5-0.6, 1.5-1.7, or 5.2-5.7 mg/kg bw/day respectively; females: 0, 0.5-0.7, 1.5-1.9 or 5.2-6.1 mg/kg bw/day respectively). The purpose of this study was to assess the effects of the continuous feeding of diets containing cyhalothrin on the reproductive performance of three generations of the rat. The fertility of each generation of parental animals and the clinical condition, survival and subsequent growth of their offspring was determined. Groups of 15 male and 30 female (F0Parents) weanling rats were fed diets containing 0, 10, 30 or l00 ppm cyhalothrin. After twelve weeks, animals were mated to produce the first (F1A) litter and subsequently re-mated to produce a second (F1B) litter. The breeding programme was repeated with F1parents selected from the F1B offspring and F2parents selected from the F2B offspring. Test diets were fed continuously through the study.
There were minor reductions in bodyweight gain of parents from all generations receiving 100 ppm cyhalothrin.
No effects of treatment were seen on indices of male and female fertility, gestation period, live born index or pup survival. There was a small reduction in mean total litter weight of the F2and F3generations from rats receiving 100 ppm cyhalothrin. This was attributable to minor decreases in litter size and a small reduction in weight gain of the pups. The effect persisted through the lactation period. Though the effect is minor it may be treatment-related. No effect was seen in litters from rats receiving 30 ppm cyhalothrin.
There was no evidence of gross or histopathological changes attributable to treatment.
The reproductive effects seen in rats receiving 100 ppm cyhalothrin were of a minor nature; 30 ppm cyhalothrin (corresponding to a minimum dose rate in the range 1.5-1.9 mg/kg/day) is established as a clear no-effect level.
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