Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-561-1 | CAS number: 108-21-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study with basic documentation.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding Toxicity Data, List V.
- Author:
- Smyth, H.F., Carpenter, C.P., Weil, C.S. and Pozzani, U.C.
- Year:
- 1 954
- Bibliographic source:
- AMA Archives of Industrial Hygiene and Occupational Medicine, 10:61-68.
Materials and methods
- Principles of method if other than guideline:
- Eye injury was recorded in a 10-grade ordinal series and was based upon the degree of corneal necrosis that results from instillation of 0.5 ml of 1% aqueous solution in the eye with results read 24 hours later. Grade 1 is at most a very small area of necrosis resulting from 0.5 ml of undiluted chemical in the eye. Grade 10 indicates a severe burn from 0.5 ml of a 1% solution in water.
- GLP compliance:
- no
- Remarks:
- study pre-dates GLP
Test material
- Reference substance name:
- Isopropyl acetate
- EC Number:
- 203-561-1
- EC Name:
- Isopropyl acetate
- Cas Number:
- 108-21-4
- Molecular formula:
- C5H10O2
- IUPAC Name:
- isopropyl acetate
- Details on test material:
- Name of test material (as cited in study report): Acetic acid, isopropyl ester
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
Amount applied: 0.5 ml or less. - Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- other: corneal necrosis
- Basis:
- other: no data
- Score:
- 2
- Max. score:
- 10
- Reversibility:
- not specified
Any other information on results incl. tables
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- isopropyl acetate received a rating of 2 in this assay.
- Executive summary:
Smyth et al (1954) reported Grade 2 corneal necrosis (on a scale of 1 min -10 max) following instillation of undiluted isopropyl acetate into rabbit eyes. This is interpreted to indicate moderate irritation potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
