Registration Dossier
Registration Dossier
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EC number: 203-311-1 | CAS number: 105-58-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro DNA damage and/or repair study
- Remarks:
- Type of genotoxicity: DNA damage and/or repair
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study in Chinese (brief english summary incl. different tables)
Data source
Reference
- Reference Type:
- publication
- Title:
- Study on three kinds of gasoline oxygenates induced DNA damage in mice fibroblasts
- Author:
- Song C, Zhang Z, Chen X, Zhang Y, Wang C & Keming L
- Year:
- 2 002
- Bibliographic source:
- China J Ind Hyg Occup Dis 20, 362-364
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Comet assay for detection of DNA damage in L 929 mice fibroblasts
- GLP compliance:
- not specified
- Type of assay:
- comet assay
Test material
- Reference substance name:
- Dimethyl carbonate
- EC Number:
- 210-478-4
- EC Name:
- Dimethyl carbonate
- Cas Number:
- 616-38-6
- IUPAC Name:
- dimethyl carbonate
- Test material form:
- other: liquid
- Details on test material:
- not further specified
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- mammalian cell line, other: L 929 mice fibroblasts
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- up to 150 mg/mL
- Vehicle / solvent:
- DMSO
Controls
- Negative solvent / vehicle controls:
- yes
- Details on test system and experimental conditions:
- not further specified
- Evaluation criteria:
- not further specified
- Statistics:
- yes
Results and discussion
Test results
- Species / strain:
- mammalian cell line, other: L 929 mice fibroblasts
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
In a Comet assay with L 929 mice fibroblasts, dimethyl carbonate gave no indications for a DNA damage at concentrations of up to 150 mg/mL - Executive summary:
In a Comet assay with L 929 mice fibroblasts, dimethyl carbonate gave no indications for a DNA damage at concentrations of up to 150 mg/mL
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