Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
secondary source
Title:
No information
Year:
1983
Bibliographic source:
Annales des Falsifications et de l'Expertise Chimique. Vol. 76(815), Pg. 65,

Materials and methods

Principles of method if other than guideline:
Method not published
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-nitrobenzaldehyde
EC Number:
209-025-3
EC Name:
2-nitrobenzaldehyde
Cas Number:
552-89-6
Molecular formula:
C7H5NO3
IUPAC Name:
2-nitrobenzaldehyde

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
600 mg/kg bw

Any other information on results incl. tables

Behavioral: altered sleep time (including change in righting eflex)

Gastrointestinal: changes in structure or function of salivary glands

Lungs, thorax or respiration: dyspnea

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
An acute oral toxicity study in mouse on the similar substance "2-nitrobenzaldehyde" reported a DL50 oral value of 600 mg/kg bw.