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Diss Factsheets
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EC number: 203-402-6 | CAS number: 106-48-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1960
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication.
Data source
Reference
- Reference Type:
- publication
- Title:
- The metabolism of halogenated benzenes: (a) penta- and hexachlorbenzenes. (b) further observations on 1:3:5-trichlorobenzene.
- Author:
- Parke DV, Williams RT
- Year:
- 1 960
- Bibliographic source:
- Biochem J 74:5-9 (Studies in Detoxication [81])
Materials and methods
- Principles of method if other than guideline:
- Investigation of the metabolic fate of penta and hexa-chlorobenzene in rabbits.
- GLP compliance:
- no
- Remarks:
- prior to GLP
Test material
- Reference substance name:
- 1,2,3,4,5-pentachlorobenzene / 608-93-5
- IUPAC Name:
- 1,2,3,4,5-pentachlorobenzene / 608-93-5
- Reference substance name:
- Hexachlorobenzene / 118-74-1
- IUPAC Name:
- Hexachlorobenzene / 118-74-1
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- Chinchilla
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Diet: 80 g/day (rat cubes, diet 41 Associated London Flour Millers)
- Water: 100 mL/day
Administration / exposure
- Route of administration:
- other: stomach tube as aqueous suspensions or subcutaneously as 10 % (w/v) solutions arachis oil
- Details on dosing and sampling:
- Urine was collected daily.
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Chromatographic evidence was obtained that 4-chlorophenol and 4-chlorocatechol are minor urinary metabolites.
Any other information on results incl. tables
Results:
1,2,3,4,5-pentachlorobenzene is only slightly altered in vivo, and hexachlorobenzene seems to be metabolically inert.
Studies of these highly chlorinated benzenes have been carried out in connection with work in this Laboratory on the metabolism of the highly chlorinated insecticides, dieldrin and aldrin, which also appear to be metabolically inert.
The substance 1,2,3,4,5-pentachlorobenzene does not have any important practical application, but hexachlorobenzene has limited use as a fungicidal agent for seeds.
Jondorf et al.(1955) were unable to account for the major portion of the dose of 1:3:5-trichlorobenzene given to rabbits. This compound has been re-investigated and it is now clear that it is not readily metabolized.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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