Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 620-056-5 | CAS number: 874195-61-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 Apr - 20 Apr 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1992
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- 1992
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1075 (Freshwater and Saltwater Fish Acute Toxicity Test)
- Version / remarks:
- Public draft, 1996
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 72-1 (Fish Acute Toxicity Test)
- Version / remarks:
- 1982/1985
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Ministerium für Arbeit, Gesundheit und Soziales des Landes Nordrhein-Westfalen
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: All replicate test concentrations were analyzed at test start, after 2 days, and after 4 days.
- Sample storage conditions before analysis: Samples were immediately analyzed. - Vehicle:
- no
- Details on test solutions:
- The test media with the test concentration was prepared after weighing of adequate amount of the test item and mixed as homogeneously as possible into glasses with test water using an ultra turrax. Afterwards the solution was transferred into the test vessels and filled up to 40 L test water.
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: Common carp
- Source: Osage Catfisheries, Osage Beach, Missouri 65065, U.S.A.
- Length at study initiation (length definition, mean, range and SD): 4.8 ± 0.3 cm
- Weight at study initiation (mean and range, SD): 1.5 ± 0.3 g
- Feeding during test: Not fed 48h before and during the study.
ACCLIMATION
- Acclimation period: At least 14 days
- Acclimation conditions (same as test or not): Same as test
- Type and amount of food: Daily with commercial trout food (Brutfutter Ecostart 17, BioMar, Denmark).
- Health during acclimation (any mortality observed): Less than 5 % mortality was noted prior to the test initiation. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 40 - 60 mg CaCO3/L
- Test temperature:
- 20.3°C - 22.6°C
- pH:
- 6.8 - 7.3
- Dissolved oxygen:
- 85 - 100 %
- Nominal and measured concentrations:
- nominal (measured): 100 mg/L (77.3 - 108 mg/L)
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 40 L fish tanks
- Material, size, fill volume: glass, 38 x 32 x 36 cm, fill volume 40 L
- No. of organisms per vessel: 15
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- Biomass loading rate: 0.56 g fish / L test medium
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Reconstituted water according to ASTM Standard E 729-1988a, Standard Guide for Conducting Acute Toxicity
Tests with fishes, Macroinvertebrates, and Amphibians. Philadelphia, PA
- Total organic carbon: < 2 mg/L
- Total suspended solids: < 5 mg/L
- Metals (mg/L): metals were shown to be below detection limit
- Pesticides: all pesticides analyzed were below detection limit
- Chloride: 0.783 mmole/L
- Conductivity: < 0.2 mS/cm
- Culture medium different from test medium: no
- Intervals of water quality measurement: Dissolved oxygen, pH, and temperature once per day
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light / 8 hours dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Observations for death, and for abnormal appearance and behavior were performed at 4, 24, 48, 72, and 96 hours (± 1 hour).
TEST CONCENTRATIONS
- Range finding study: Based on a range finder test (non-GLP), the definitive test concentration was set at 100 mg test item / L (limit test) - Reference substance (positive control):
- yes
- Remarks:
- Copper(II)sulfate
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 77.3 - 108 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Details on results:
- All 30 fish showed no symptoms at this test concentration of 100 mg/L (nominal).
- Results with reference substance (positive control):
- The sensitivity of fish against the reference substance Copper(II)sulfate (CuSO4) was tested separately, resulting in a 96h-LC50 of 62.3 μg/L.
- Sublethal observations / clinical signs:
Table 1: Number of dead test organisms
Contr (1)
Contr (2)
100 mg/L (1)
100 mg/L (2)
4h
0
0
0
0
Day 1
0
0
0
0
Day 2
0
0
0
0
Day 3
0
0
0
0
Day 4
0
0
0
0
Table 2: Recoveries based on nominal concentration
100 mg/L (1)
100 mg/L (2)
Day 0
79.4%
172%
Day 2
77.6%
75.7%
Day 4
74.8%
75%
Mean
Day 0-4
77.3%
108%
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 Mar - 26 Apr 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1992
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- 1992
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1075 (Freshwater and Saltwater Fish Acute Toxicity Test)
- Version / remarks:
- Public draft, 1996
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 72-1 (Fish Acute Toxicity Test)
- Version / remarks:
- 1982/1985
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Ministerium für Arbeit, Gesundheit und Soziales des Landes Nordrhein-Westfalen
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: All replicate test concentrations were analyzed at test start, after 2 days, and after 4 days.
- Sample storage conditions before analysis: Samples were immediately analyzed. - Vehicle:
- no
- Details on test solutions:
- The test media with the test concentration was prepared after weighing of adequate amount of the test item and mixed as homogeneously as possible into glasses with test water using an ultra turrax. Afterwards the solution was transferred into the test vessels and filled up to 40 L test water.
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Source: Hatchery Forellenzucht Trostadt, 98646 Trostadt, Germany.
- Length at study initiation (length definition, mean, range and SD): 5.1 ± 1.0 cm
- Weight at study initiation (mean and range, SD): 1.6 ± 1.0 g
- Feeding during test: Not fed 48h before and during the study.
ACCLIMATION
- Acclimation period: At least 14 days
- Acclimation conditions (same as test or not): Same as test
- Type and amount of food: Daily with commercial trout food (Brutfutter Ecostart 17, BioMar, Denmark).
- Health during acclimation (any mortality observed): Less than 5 % mortality was noted prior to the test initiation and all unsuitable fish (e.g. injured, deformed, etc.) were eliminated from the test prior to the assignment of test groups. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 40 - 60 mg CaCO3/L
- Test temperature:
- 11.4°C – 12.3°C
- pH:
- 6.7 - 7.3
- Dissolved oxygen:
- 85 - 101 %
- Nominal and measured concentrations:
- nominal (measured): 100 mg/L (88.4 mg/L)
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 40 L fish tanks
- Material, size, fill volume: glass, 38 x 32 x 36 cm, fill volume 40 L
- No. of organisms per vessel: 15
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- Biomass loading rate: 0.60 g fish / L test medium
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Reconstituted water according to ASTM Standard E 729-1988a, Standard Guide for Conducting Acute Toxicity
Tests with fishes, Macroinvertebrates, and Amphibians. Philadelphia, PA
- Total organic carbon: < 2 mg/L
- Total suspended solids: < 5 mg/L
- Metals (mg/L): metals were shown to be below detection limit
- Pesticides: all pesticides analyzed were below detection limit
- Chloride: 0.783 mmole/L
- Conductivity: < 0.2 mS/cm
- Culture medium different from test medium: no
- Intervals of water quality measurement: Dissolved oxygen, pH, and temperature once per day
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light / 8 hours dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Observations for death, and for abnormal appearance and behavior were performed at 4, 24, 48, 72, and 96 hours (± 1 hour).
TEST CONCENTRATIONS
- Range finding study: Based on a range finder test (non-GLP), the definitive test concentration was set at 100 mg test item / L (limit test) - Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 88.4 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Details on results:
- The test concentration of 88.4 mg/L a.i. (nominal 100 mg/L) did not cause any mortality to Rainbow trout. So the 96h-LC50 is clearly above 88.4 mg a.s. / L.
- Sublethal observations / clinical signs:
Table 1: Number of dead test organisms
Contr (1)
Contr (2)
100 (88.4) mg/L (1)
100 (88.4) mg/L (2)
4h
0
0
0
0
Day 1
0
0
0
0
Day 2
0
0
0
0
Day 3
0
0
0
0
Day 4
0
0
0
0
Table 2: Recoveries based on nominal concentration
100 mg/L (1)
100 mg/L (2)
Day 0
138%
106%
Day 2
79%
74%
Day 4
70%
64%
Mean
Day 0-4
96%
81%
Referenceopen allclose all
Description of key information
Cyprinus carpio LC50 (96h) > 77.3 - 108 mg/L (mean measured)
Oncorhynchus mykiss LC50 (96h) > 88.4 mg/L (mean measured)
Key value for chemical safety assessment
Additional information
Two studies are available on the short-term toxicity of triafamone (CAS No. 874195-61-6) to fish (Buns, 2010; 2013). The studies were performed according to OECD guideline 203 and GLP, with analytical monitoring of the test item concentration. The mean recovery rates ranged between 77.3% - 108% and 81% - 96%, respectively. Different test species were used in the two studies. One study was conducted with the common carp (Cyprinus carpio) and the other study with the rainbow trout (Oncorhynchus mykiss) as test organism. Both fish species showed no mortality at the highest test item concentration of 100 mg/L (nominal). Based on the measured concentrations a LC50 (96h) > 77.3 - 108 mg/L triafamone is reported for Cyprinus carpio and a LC50 (96h) > 88.4 mg/L triafamone for Oncorhynchus mykiss.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.