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EC number: 403-920-4 | CAS number: 107551-67-7 G 19-675 ZP
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Jun. 27, 1988 to Aug. 8, 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented, according to accepted guideline, with GLP-like Quality Assurance
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- Test performed as limit test with conc. 100 mg/l nominal. Highest vehicle concentration 950 mg/l; acclimatisation 11 days
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-(3-tert-butyl-4-hydroxyphenyl)propionic acid
- EC Number:
- 403-920-4
- EC Name:
- 3-(3-tert-butyl-4-hydroxyphenyl)propionic acid
- Cas Number:
- 107551-67-7
- Molecular formula:
- C13H18O3
- IUPAC Name:
- 3-(3-tert-butyl-4-hydroxyphenyl)propanoic acid
- Details on test material:
- - Physical state: beige crystalls
- Analytical purity: commercial grade
- Lot/batch No.: EN.116905.72
- Expiration date of the lot/batch: 11/92
- Storage condition of test material: room temperature
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 100 mg/L.
- Sampling method: Samples for analysis were taken at the start and at the end of the exposure.
- Sample storage conditions before analysis: Not available.
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- Stock solution: 5.0 g test substance were dissolved in and made up to 50 ml with DMF.
Highest vehicle concentration: 950 mg/L.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebra-Fish.
- Source: West Aquarium / D-3422 Bad Lauterberg.
- Length at study initiation (length definition, mean, range and SD): 20 mm (16-25 mm).
- Weight at study initiation (mean and range, SD): 0.06 g (0.03-0.11 g).
ACCLIMATION
- Acclimation period: 11 days.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- Not applicable.
Test conditions
- Hardness:
- 188 mg CaC03/L.
- Test temperature:
- 23 ± 1°C.
- pH:
- 8.0-8.5.
- Dissolved oxygen:
- 93-102%.
- Salinity:
- freshwater
- Nominal and measured concentrations:
- Nominal concentration: 100 mg/L . Refer to Table 1.
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass aquaria of 20 liters filled with 15 liters (36/22/25 cm).
- Type (delete if not applicable): open
- Aeration: None
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
- Biomass loading rate: 0.04 g/l
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Dechlorinated tap water (carbon filter).
- Intervals of water quality measurement: oxygen, pH, temperature daily
OTHER TEST CONDITIONS
- Photoperiod: Fluorescent light, 16 hours daily.
EFFECT PARAMETERS MEASURED (with observation intervals if applicable):
Mortalities, swimming behaviour, loss of equilibrium, respiratory function, exophtalmus, and pigmentation observed 24, 48, 72 and 96 hours - Reference substance (positive control):
- not required
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: None
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: None
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: None
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: None
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: None
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: None
- Details on results:
- Refer to Tables 2 and 3.
- Results with reference substance (positive control):
- Mortalities in blank (water) : 0%
Mortalities in vehicle (DMF) : 0% - Reported statistics and error estimates:
- None.
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Table 2. Mortalities
Concentration
nominal
mg/ L
Mortalities
Number of dead fishes
24 h
48 h
72 h
96 h
Blank
0
0
0
0
Vehicle
0
0
0
0
100
0
0
0
0
100
0
0
0
0
Table 3 Symptoms observed at the different test concentrations
Concentration
nominal
mg/ L
Swimming behaviour
Loss of equilibrium
Respiratory function
Exophtalmus
Pigmentation
24
48
72
96h
24
48
72
96h
24
48
72
96h
24
48
72
96h
24
48
72
96h
Blank
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
Vehicle
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
100
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
100
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
Effect :
0: normal
1: slight
2: moderate
3: severe
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.