Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 610-992-2 | CAS number: 53378-52-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 18, 2011 - July 7, 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- yes
- Remarks:
- open aluminum pans were used under nitrogen purge at 25 mL/min. This is a discrepancy from the OECD guideline. The OECD guideline calls for a plate instead of a pan.
- Qualifier:
- according to guideline
- Guideline:
- other: ST-AN-25
- Deviations:
- no
- Principles of method if other than guideline:
- The vapor pressure of the test substance was determined by effusion method: isothermal thermogravimetry (TGA). The TGA method is based on the determination of accelerated evaporation rates for the test substance at elevated temperatures and ambient pressure. This method is suitable for substances with vapor pressures as low as 10E-10 Pa (10-12 mbar) and with purity as close as possible to 100% to avoid the misinterpretation of measured weight losses. The estimated repeatability is 10 to 30% and the estimated reproducibility is up to 50%. However, incorporating NIST traceable standard reference materials and open pans, the reproducibility and accuracy is much higher.
TGA experiments were conducted using a Q5000 TGA following ST-AN-25 procedure. Open aluminum pans were used under nitrogen purge at 25 mL/min. This is a discrepancy from the OECD Guideline. The OECD Guideline calls for a plate instead of a pan. The diameter of the pan is 6 mm. The sample weight of the benzoic acid and test substance is approx. 20 mg. This is enough material to keep the surface area consistent throughout the analyses.
Isotherms at appropriate temperatures were conducted until weight loss rate was stable. The instrument software was used to calculate the evaporation rate by taking the slope when weight loss rate is constant. The evaporation rate was then plotted against the literature vapor pressure values of benzoic acid in order to obtain a calibration equation for the instrument parameters. Other compounds of known vapor pressures were also analyzed against the benzoic acid calibration curve in order to validate the method. - GLP compliance:
- no
- Type of method:
- effusion method: isothermal thermogravimetry
Test material
- Reference substance name:
- Sodium O,O-diisobutyl phosphorothioate
- EC Number:
- 610-992-2
- Cas Number:
- 53378-52-2
- Molecular formula:
- C8 H18 O3 P S . Na
- IUPAC Name:
- Sodium O,O-diisobutyl phosphorothioate
- Test material form:
- other: grease-like solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): S10821; AERO® 6697 Promoter distilled
- Name: Sodium diisobutyl monothiophoshate
- CAS: 53378-52-2
- Molecular formula: C8H18O3PS.Na
- Molecular weight: 248.26
- Storage condition of test material: not indicated in the study report
- Batch no.: 20154-189-B
- Purity: 87.3%
Results and discussion
Vapour pressureopen allclose all
- Temp.:
- 25 °C
- Vapour pressure:
- ca. 0.026 Pa
- Temp.:
- 20 °C
- Vapour pressure:
- ca. 0.024 Pa
Any other information on results incl. tables
The vapor pressure equation with mm Hg units is:
Y = -708.72X - 1.325
where Y = log pressure (mmHg), and X = 1/K. The R2 = 0.9992.
The converted vapor pressure equation to Pa pressure unit is:
Y = -708.15X + 0.7982
where Y = log Pressure (Pa), and X = 1/K. The R2 = 0.9992
Experimental Evaporation Rates on the Test Substance and Calculated Vapor Pressure.
Evaporation Rate |
Temperature |
Calculated Vapor Pressure |
|||
Wt%/min |
Log Wt%/min |
°C |
1/K |
Log P (mmHg) |
P (mmHg) |
0.0000655 |
-4.1837587 |
50 |
0.003095 |
-3.5160 |
0.000305 |
0.0000745 |
-4.127843727 |
60 |
0.003002 |
-3.4570 |
0.000349 |
0.00009875 |
-4.005462896 |
80 |
0.002832 |
-3.3278 |
0.00047 |
0.0001242 |
-3.905878404 |
100 |
0.002680 |
-3.2226 |
0.000599 |
0.0001229 |
-3.910448117 |
100 |
0.002680 |
-3.2275 |
0.000592 |
Applicant's summary and conclusion
- Conclusions:
- The estimated vapor pressure of the test substance at 20 °C is 0.000181 mmHg (0.0241 Pa) and at 0.000199 mmHg (0.0265 Pa) at 25 °C. Both values were determined using a method similar to OECD 104 guideline.
- Executive summary:
Using the isothermal thermogravimetric effusion method, the vapour pressure of the substance at 25°C has been determined as 0.0265 Pa.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.