Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-354-6 | CAS number: 106-02-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
No information about the abiotic degradation of the substance is available. But as the substance is readily biodegradable (two reliable screening studies fulfilling the 10-day window), the substance is considered rapidly degradable in the environment. Therefore, no environmental persistence of the substance is anticipated and no further tests on degradation in the environment are necessary.
The adsorption potential of the substance was evaluated in a GLP OECD 121 study on a read-across substance (EC number: 422-320-3) in which a Koc of 44500 was determined. The substance can be considered as strongly binding to soil and sediment and therefore immobile in soil and sediments based on the system proposed by McCall et al. (1980). This supporting substance is considered adequate for read-across purposes (see Iuclid section 13 for justification).
Furthermore, it is assumed that the substance evaporates from water surfaces under environmental conditions due to its high Henry’s Law constant (68.1 Pa.m3/mol at 25°C).
The BCF of the substance was calculated using the BCF/BAF method of Arnot-Gobas including biotransformation rate, resulting in a BCF value between 500 and 1000 regardless of the trophic level. The B criterion is not fulfilled for the substance and thus, the substance is considered to be not bioaccumulative. It would be technically challenging to perform a BCF study on fish at concentrations below the NOEC (of 0.027 mg/L) as apart from the low water solubility, the substance also has a high adsorption coefficient and readily biodegrades. Furthermore the ready degradation implies rapid metabolism so significant bioaccumulation is not expected and an experimental BCF study would not be expected to add significantly to the knowledge already gained for bioaccumulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.