Registration Dossier
Registration Dossier
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EC number: 223-460-6 | CAS number: 3905-19-9
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
- Principles of method if other than guideline:
- Two complementary and independent approaches to assess surface reactivity: Ferric Reduction Ability in Serum (FRAS) assay and the standardized Electron Paramagnetic Resonance with Spin Trap (EPR:DMPO).
- GLP compliance:
- no
- Type of method:
- other: in chemico
- Endpoint addressed:
- repeated dose toxicity: inhalation
Test material
- Reference substance name:
- N,N'-phenylene-1,4-bis[4-[(2,5-dichlorophenyl)azo]-3-hydroxynaphthalene-2-carboxamide]
- EC Number:
- 223-460-6
- EC Name:
- N,N'-phenylene-1,4-bis[4-[(2,5-dichlorophenyl)azo]-3-hydroxynaphthalene-2-carboxamide]
- Cas Number:
- 3905-19-9
- Molecular formula:
- C40H24Cl4N6O4
- IUPAC Name:
- N,N'-phenylene-1,4-bis[4-[(2,5-dichlorophenyl)azo]-3-hydroxynaphthalene-2-carboxamide]
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- Purity: 99.4 %
Red powder
Administration / exposure
- Details on study design:
- It is referred to the attached study report.
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The authors employed two complementary and independent approaches to assess surface reactivity, namely the Ferric Reduction Ability in Serum (FRAS) assay and the standardized Electron Paramagnetic Resonance with Spin Trap (EPR:DMPO). The pigment did not induce oxidative damage significantly above the blank control and is considered as passive in the FRAS assay. Also in the complementary EPR assay, Pigment Red 166 induced a reactivity that is compatible with or below the blank control and are classified as passive.
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