Registration Dossier
Registration Dossier
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EC number: 426-040-2 | CAS number: 25713-60-4 SR-245
Endpoint summary
Administrative data
Description of key information
Additional information
FR-245 is a hydrophobic molecule with molecular weight of 1067g/mol. The substance has an extremely low water solubility of < 1 μg/l, and a high estimated of log Pow = 8.63.Accordingly, it seems very unlikely that the substance will be available for aquatic organisms through the water compartment.
The bioaccumulation potential of FR-245 was assessed in a bioconcentration test. Fish were exposed to 0.5 mg/l which is much above the maximum level of water solubility of the substance. Therefore, although no bioconcentration was observed, valid results cannot be derived due to the concentrations used.
Performing the study at the level of water solubility is technically impossible since the concentrations of the substance in water cannot be confirmed. However, results from the ADME study in rats show only minor absorption and retention of FR-245 in tissues (<0.2%), indicating virtually negligible uptake of the substance.These findings furthersupport the conclusion that FR-245 will not be bioavailable and therefore will not bioaccumulate.
The persistency of the substance was investigated and confirmed in simulation tests conducted in water sediment systems. The transformation of14C- FR-245 was assessed in aerobic and anaerobic systems. The DT50 calculated from the simulation studies exceeded 180 days under both conditions. The results of these studies indicate that FR-245 can be considered as very persistent (vP).
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