Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-963-7 | CAS number: 112-36-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study undertaken at GLP accredited laboratory to internationally accepted guidelines. The restriction is due to the use of read across approach: the study was performed not with DEGDEE but with DEGEE, a substance which like DEGDEE is part of the diethylene glycol monoalkyl and dialkyl ethers category. These substances have been demonstrated to be similar in structure, physical/chemical properties and toxicological profile.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-(2-ethoxyethoxy)ethanol
- EC Number:
- 203-919-7
- EC Name:
- 2-(2-ethoxyethoxy)ethanol
- Cas Number:
- 111-90-0
- Molecular formula:
- C6 H14 O3
- IUPAC Name:
- 2-(2-ethoxyethoxy) ethanol
- Reference substance name:
- Diethylene glycol ethyl ether
- IUPAC Name:
- Diethylene glycol ethyl ether
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report):Diethylene glycol monoethyl ether (DGME)
- Molecular formula (if other than submission substance): C6H14O3
- Molecular weight (if other than submission substance): 134.2
- Substance type: Organic
- Physical state: Liquid
- Analytical purity: 98.1
- Main Impurities: ethylene glycol 1.4%, ethylglycol 0.26%
- Lot/batch No.:3641/ 85472
- Storage condition of test material: Room temperature and humidity in a fume cupboard.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: UK
- Age at study initiation: approximately 6 weeks
- Weight at study initiation: group mean bodyweights (g) was between 135.4 and 169.0
- Fasting period before study:
- Housing: The animals were housed and exposed in a single room. The rats were kept 5 of the same sex to a cage, suspended on a movable rack.
Each cage had stainless steel mesh front, back and floor and stainless steel sides. The dimensions were 53 cm long, 35 em wide and 25 cm high. Plastic trays lined with absorbent paper, were placed below the cages to collect the animal excreta. The paper was changed daily.
- Diet (e.g. ad libitum): standard quality controlled laboratory rat food
- Water (e.g. ad libitum): tap water
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19.5- 23.0
- Humidity (%): 40-60
- Photoperiod (hrs dark / hrs light): 12hrs dark and 12 hr light
IN-LIFE DATES: From: 21 November 1990 (animals arrived) To: 17 December 1990 (terminal kill Group 3)
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: ADG snout-only inhalation chamber (with 20 exposure ports)
- Exposure chamber volume:approximately 50 litres.
- Chamber temperature: 22°C (mean)
- Method of holding animals in test chamber: push rod in tapered chamber
- Source and rate of air: Air was withdrawn from the base of the chamber at a rate of 30 litres per minute. The air was withdrawn by a vacuum pump through filtration media, to remove particulate and silica gel to remove excess moisture.
The extract and inlet air supplies were balanced by allowing air to be drawn through a Cambridge filter, into the tangential inlet duct at the top of the chamber.
- Pressure in air chamber: 10 l/min, which corresponded to an inlet pressure of 86 psig
TEST ATMOSPHERE
- Brief description of analytical method used: The test substance was metered from an all polypropylene disposable syringe
mounted on an infusion pump, via a PTFE tube, to a stainless steel concentric jet atomiser. The atomiser was set into the base
of an aluminium and glass elutriation column.
Clean, dried compressed air was supplied to the atomiser at 10 litres per minute. The test substance aerosol was introduced into the elutriation column where it was mixed with diluent air introduced at a rate of 15 litres per minute. The aerosol laden air pased into the exposure chamber.
- Particle size distribution: Two samples taken during exposure period. Analysis using a Marple 296 cascade impactor at a rate of 2 l/min. Exposure mean less than 6um aerodynamic diameter: Low concentration 96.5%, high concentration 92.1%.
- MMAD (Mass median aerodynamic diameter) Low concentration: 4.153, high concentration 3.855 um. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 1. (Air control) air only
2. (Test) 3.73
3. (Test) 5.24 - No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The rats were observed continuously throughout exposure for signs of
reaction to the test substance and at least twice daily throughout the 14-day observation period. All rats were weihgt daily from the day of arrival up to and including the day of death.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,food consumption, water consumption
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.24 mg/L air
- Based on:
- test mat.
- Remarks on result:
- other: aerosol exposure
- Mortality:
- There were no deaths during the study.
- Clinical signs:
- other: There were no signs related to exposure to DGME.
- Body weight:
- There were no treatment-related differences.
- Gross pathology:
- Macroscopic pathology: Pale, raised areas were seen on the lungs of 3/5 males and 1/5 females exposed to 5.24 mg/l. Dark spots were seen on the lungs of 1/5 males exposed to 5.24 mg/l.
Microscopic pathology: Minimal centrilobular hepatocyte enlargement in 3/5 males exposed to 5.24 mg/l. - Other findings:
- - Lung weight to bodyweight ratios: All ratios are considered to be within normal limits.
- Water consumption: There were no treatment-related differences.
- Food consumption: There were no treatment-related differences.
- Histopathology: High dose group: minimal centrilobular hepatocyte enlargement in 3/5 males. The authors of the study considered this to be related to exposure and speculated that it may indicate a work hypertrophy. Low dose group: no significant observations.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LC50 for Diethylene glycol ethyl ether when exposed to aerosols was found to be >5.24mg/l in rats.
- Executive summary:
DEGDEE and DEGEE, which is in the above study tested for its acute inhalation toxicity in rats, are both part of the diethylene glycol monoalkyl and dialkyl ethers category described and evaluated in the document titled "Category Approach-Read across Bis(2 -ethoxyethyl)ether" (2013).
These substances have been demonstrated to be very similar in structure, physical/chemical properties and toxicological profile . Therefore, a read-across from DEGDEE to data obtained with DEGEE is scientifically justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.