2-Butanol, 2-methyl-, lithium salt (1:1)

Skin irritation / corrosion

Administrative data

Endpoint:

skin corrosion: in vitro / ex vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

2012-03-29 to 2012-04-02

Reliability:

2 (reliable with restrictions)

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2012

Report date:

2012

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Corrositex TM is a quantitative in vitro corrosivity test. The model is based on the time required for the test substance to pass through a biobarrier membrane and produce a change in a chemical detection system.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

485-110-0

EC Name:

-

Cas Number:

53535-81-2

Molecular formula:

Hill formula: C5H11LiO CAS formula: C5H12O.Li

IUPAC Name:

lithium(1+) 2-methylbutan-2-olate

Constituent 2

Reference substance name:

Lithium 2-methylbutan-2-olate

IUPAC Name:

Lithium 2-methylbutan-2-olate

Test animals

Species:

other: n.a.

Strain:

other: n.a.

Details on test animals or test system and environmental conditions:

Not indicated; in vitro test

Test system

Type of coverage:

other: n.a.

Preparation of test site:

other: n.a.

Vehicle:

other: n.a.

Controls:

no

Amount / concentration applied:

not indicated

Duration of treatment / exposure:

not indicated

Observation period:

not indicated

Number of animals:

not indicated

Details on study design:

The international Corrositex assay kit is an In vitro method for determining the corrosive potential of chemical substances. The results of this assay were used to determine the United Nations Transport Regulations Packaging Group. For detailed test procedure see Sect. "Any other information on materials and methods incl. tables"

Results and discussion

In vivo

Irritant / corrosive response data:

The results of the categorization screen indicated that the test article, Lithium t-Amoxide, fell into category 1. For further Information, see Sect. "Remarks on results incl. tables and figures"

Other effects:

none

Any other information on results incl. tables

One run has been performed:

Sample Nr.	1	2	3	4
Detection Time hr:min:sec	00:26:05	00:26:05	00:26:05	00:26:05
Start Time	00:00:00	00:01:36	00:03:12	00.04:46
CORROSITEX Time	00:26:05	00:24:29	00:22:53	00:21:19
Convert to Minutes	26.08	24.48	22.88	21.32
Mean of 4 Replicates	23.69

 

According to the results of the Corrositex TM Assay, the test article, Lithium t-Amoxide, has to be classified as corrosive and allocated to packing group II according to the UN Dangerous Goods Transport Regulations

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information Criteria used for interpretation of results: other: UN Dangerous Goods Transport Regulations

Conclusions:

Lithium t-Amoxide was tested for corrosive properties in the Corrositex TM Assay which is used for assigning the packaging group according to UN Dangerous Goods Transport Regulations. Lithium t-Amoxide was found to be corrosive and assigned to packing group II. Lithium t-Amoxide has to be classified as corrosive Cat . 1B (H314) according to Regulation (EC) No 1272/2008 (CLP) and Corrosive R34 according to Directive 67/548/EEC.

Executive summary:

Studies to determine the animal toxicity cannot be performed with Lithium t-Amoxide because of its reactivity and corrosive properties. Lithium t-Amoxide is pyrophoric and would react violently on exposure to animal tissues, Instead, Lithium t-Amoxide was tested for skin irritation/corrosion. Lithium t-Amoxide was tested for corrosive properties in the Corrositex TM Assay which is used for assigning the packaging group according to UN Dangerous Goods Transport Regulations. Lithium t-Amoxide was found to be corrosive and assigned to packing group II.

Based on this data the substance is also found to be:

- corrosive: Cat. 1B (H314) according to Regulation (EC) No 1272/2008 (CLP) and

- corrosive (R34) according to Directive 67/548/EEC.