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EC number: 251-807-1 | CAS number: 34041-09-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012-12-18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Version / remarks:
- adopted 2006-07-19
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: ICCVAM Minimum Performance Standards: In Vitro Membrane Barrier Test Systems for Skin Corrosion, June 23, 2003
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: ICCVAM Recommended Performance Standards for in vitro Test Methods for Skin Corrosion (May 2004)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 2009-03-30
Test material
- Reference substance name:
- 2-ethylhexanoic acid, molybdenum salt
- EC Number:
- 251-807-1
- EC Name:
- 2-ethylhexanoic acid, molybdenum salt
- Cas Number:
- 34041-09-3
- Molecular formula:
- C8H16O2.xMo
- IUPAC Name:
- 2-ethylhexanoic acid, molybdenum salt
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): 2-ethylhexanoic acid, molybdenum salt
- Chemical Name: molybdenum 2-ethylhexanoate
- Physical state: brown, liquid
- Storage condition of test material: at room temperature, under nitrogen (further detailed: Harlan CCR SOP SUBST.doc)
Constituent 1
Test animals
- Details on test animals or test system and environmental conditions:
- Not applicable - Since this is an in vitro study there is no information on test animals.
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 μL of the test item were dispensed directly atop the bio-barrier. - Duration of treatment / exposure:
- 60 minutes
- Observation period:
- not applicable
- Number of animals:
- not applicable
- Details on study design:
- TEST SYSTEM
- Test kit:
Name: Corrositex™
Supplier: Transia GmbH, 61239 Ober-Mörlen, Germany
Lot No.: CT052112)
- Preparation of the bio-barrier:
One day prior to testing the bio-barrier matrix was prepared. The bio-barrier powder was solved in the bio-barrier diluent and heated for 20 ± 2 minutes at 68 – 70 °C in a water bath under continuous stirring. The temperature did not exceed 70 °C. The mixture was allowed to cool in the turned-off water bath for another 10 minutes. The mixture was then filled into the membrane holders (200 µL per membrane holder). Air bubbles were avoided. The filled membrane holders were sealed with parafilm and were stored at 2 – 8 °C until further use.
EXPERIMENTAL PERFORMEANCE
- Qualify Test: to test whether the test system is suitable for the test item, 150 μL of the test item were applied into the “Qualify Test Vial”. The vial was shaken until the solution appeared homogenous, and incubated for at least 1 minute. Afterwards, the colour change was noted. Since a change in colour was visible in the “Qualify Test Vial”, the test item was considered to be suitable for the next step.
- Categorisation Test: the test item was categorised according to the pH value method described in the manufacturer’s manual.
A 10% dilution (v/v) of the test item in deionised water was prepared. The pH value of the dilution was determined. Test items with a pH value of < 7 were added to the “Category A Vial” and test item with a pH value of > 7 were added to the “Category B Vial”. The vial was closed, shaken, and the pH value was determined. Test items showing a pH value ≤ 5 in the “Category A Vial” were assigned to category 1 and test items showing a pH value of ≥ 5
were assigned to category 2. Test items showing a pH value of ≥ 9 in “Category B Vial” were assigned to category 1 and test items showing a pH value of ≤ 9 were assigned to category 2. Since the pH value of the test item dilution in the category A vial was 7.5 the test item was assigned to category 2.
- Classification Test: 7 vials containing the CDS were pre-warmed to room temperature. 4 vials were used for quadruplicate measurement of the test item, one vial was used for the positive control (single measurement), and one vial was used for the negative control (single measurement). The one vial was used as colour reference for the CDS.
The prepared bio-barriers were placed atop the CDS vials (not longer than 2 min prior to application) and 500 μL of the test item or controls (positive control: sulfuric acid 95-97% (lot no. K40281631 929, Merck, 64295 Darmstadt, Germany); negative control: citric acid (lot no. 140986235008107, Sigma, 89555 Steinheim, Germany, 10% (w/v) solution in deionised water)), respectively, were applied per bio-barrier for 1 hour or 4 hours, depending on the results of the categorisation test. The time interval of the possible colour change or precipitation in the CDS solution was recorded.
INTERPRETATION OF THE RESULTS
For each vial the time until observable change in CDS solution was determined. The mean of the quadruplicate measurement the mean was calculated. The test item was categorised according to the following table as can be seen in the field "Any other information on materials and methods incl. tables" below (Table 1).
ACCEPTABILITY OF THE ASSAY
The results are considered as valid if the following acceptance criteria are met:
The test item induces a physical change (colour or precipitation) in the CDS solution in the qualify test.
The negative control does not induce a physical change (colour or precipitation) < 60 minutes in the CDS solution in the classification test.
The positive control induces a physical change (colour or precipitation) in the CDS solution in the classification test after 0 – 3 minutes.
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: other: time interval of colour change of CDS reagent after treatment of bio-barrier
- Value:
- 0
- Remarks on result:
- other:
- Remarks:
- Basis: other: minutes (mean of 4 replicates). Time point: after 60 minutes of treatment. Remarks: A change of colour of CDS reagent after treatment of bio-barriers with test item was not observed during the test, i.e. for 60 minutes. . (migrated information)
In vivo
- Irritant / corrosive response data:
- A change of colour of the CDS reagent after treatment of the bio-barriers with the test item was not observed up to 60 minutes. According to the classification criteria the test item was classified as non corrosive.
Any other information on results incl. tables
HISTORICAL DATA:
Table: Historical data
Mean time till colour change of positive control [min] |
1.313 |
Standard Deviation [min] |
0.45 |
Data of 46 studies performed from 2006 till 2012.
QUALIFY TEST:
The test item induced a change in colour in the qualify test after 1 minute incubation. Since a change in colour was visible in the “Qualify Test Vial”, the test item was considered to be suitable for the next step.
CATEGORISATION TEST:
Since the pH value of the test item in the “Category A Vial” was 7.5 and therefore above 7 the test item was assigned to category 2.
CLASSIFICATION TEST:
Test Group
|
Time Interval of
|
UN Packaging Group
|
R-Sentence
|
GHSand Regulation (EC) No 1272/2008 (CLP)
|
Negative Control
|
Colour change was not observed for 60 minutes
|
- |
- |
- |
Positive Control
|
1 minute
|
I
|
R35
|
1A
|
Test Item
|
Colour change was not observed for 60 minutes
|
Non-corrosive
|
|
|
- The negative control did not induce a change in the colour of the CDS reagent after 60 minutes. The positive control showed a distinct change in the colour of the CDS reagent in the time interval of 0 – 3 minutes (after 1 minute). These results ensured the validity of the test.
Applicant's summary and conclusion
- Interpretation of results:
- other: the test item is not corrosive.
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- In conclusion, it can be stated that in this study and under the experimental conditions reported, the test item 2-ethylhexanoic acid, molybdenum salt is not corrosive to skin.
According to the EC-Commission directive 67/548/EEC and its subsequent amendments, the test substance is not classified as corrosive to the skin.
According to the EC-Regulation 1272/2008 and subsequent regulations, the test item is not classified as corrosive to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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