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Diss Factsheets
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EC number: 203-187-9 | CAS number: 104-23-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Experimental results of test chemicals
- Justification for type of information:
- Data for the target chemical is summarized based on the test chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two hydrolysis studies as- 1. and 2.
- GLP compliance:
- not specified
- Transformation products:
- not specified
- pH:
- 7
- Hydrolysis rate constant:
- 2.9 s-1
- DT50:
- 276 d
- Type:
- not specified
- Remarks on result:
- other: 1.Hydrolysis rate const. 2.9X10+9 L/mol-sec
- Remarks:
- other details not available
- Temp.:
- 25 °C
- DT50:
- 10.3 yr
- Type:
- not specified
- Remarks on result:
- other: 2.at pH 2.96, 7, and 10.95
- Remarks:
- other details not available
- Key result
- Temp.:
- 25 °C
- DT50:
- 11 yr
- Type:
- not specified
- Remarks on result:
- other: 2.at pH 2.96, 7, and 10.95
- Remarks:
- other details not available
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 276 days at pH 7 and was 11.11, 11, and 10.73 year at pH 2.96, 7, and 10.95 respectively at 25 deg C. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.
- Executive summary:
Various studies have been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:
In first study, the hydrolysis rate constant of chemical obtained was 2.9X10+9 L/mol-sec L/mol/sec. The half-life of hydrolysis obtained at pH 7 was 276 days. Since half-life of hydrolysis is more than 10 days so it is concluded that test chemical shows negligible hydrolysis that means it is not hydrolysable.
In another study, the half-life of hydrolysis obtained at pH 2.96, 7, and 10.95 at 25 deg C was 11.11, 11, and 10.73 year respectively. Since half-life of hydrolysis is more than 10 days so it is concluded that test chemical shows negligible hydrolysis. Thus it is concluded as not hydrolysable.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 276 days at pH 7 and was 11.11, 11, and 10.73 year at pH 2.96, 7, and 10.95 respectively at 25 deg C. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.
Reference
Description of key information
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 276 days at pH 7 and 11.11, 11, and 10.73 year at pH 2.96, 7, and 10.95 respectively at 25 deg C. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.
Key value for chemical safety assessment
Additional information
Various studies have been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:
In first study, the hydrolysis rate constant of chemical obtained was 2.9X10+9 L/mol-sec L/mol/sec. The half-life of hydrolysis obtained at pH 7 was 276 days. Since half-life of hydrolysis is more than 10 days so it is concluded that test chemical shows negligible hydrolysis that means it is not hydrolysable.
In another study, the half-life of hydrolysis obtained at pH 2.96, 7, and 10.95 at 25 deg C was 11.11, 11, and 10.73 year respectively. Since half-life of hydrolysis is more than 10 days so it is concluded that test chemical shows negligible hydrolysis. Thus it is concluded as not hydrolysable.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 276 days at pH 7 and was 11.11, 11, and 10.73 year at pH 2.96, 7, and 10.95 respectively at 25 deg C. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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