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nonapotassium 2,4,6-trihydroxy-4-methyl-3,5-dioxa-2,4,6-trisilaheptane-2,6-bis(olate) 2,6,8-trihydroxy-4,6-dimethyl-3,5,7-trioxa-2,4,6,8-tetrasilanonane-2,4,8-tris(olate) 6-hydroxy-2,4,6-trimethyl-1,3,5,2,4,6-trioxatrisilinane-2,4-bis(olate) dihydroxy(methyl)silanolate {[dihydroxy(methyl)silyl]oxy}(hydroxy)methylsilanolate
EC number: 935-877-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2002-04-15 to 2002-06-13
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the appropriate OECD test guideline, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Potassium methylsilanetriolate
- EC Number:
- 250-807-9
- EC Name:
- Potassium methylsilanetriolate
- Cas Number:
- 31795-24-1
- IUPAC Name:
- tripotassium methylsilanetriolate
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- S. typhimurium TA 102
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor induced rat liver S9
- Test concentrations with justification for top dose:
- 100-5000 µg/plate
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: water
- Justification for choice of solvent/vehicle: none given in report
Controlsopen allclose all
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- Water
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- sodium azide
- Remarks:
- TA 1535, TA 100 (without activation)
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- Water
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- 2-nitrofluorene
- Remarks:
- TA 98 (without activation)
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- Water
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- Remarks:
- TA 1537 (without activation)
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- Water
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- methylmethanesulfonate
- Remarks:
- TA 102 (without activation)
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- Water
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: 2-anthracene amide
- Remarks:
- TA 98, TA 102, TA 1537 (with activation)
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- Water
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- cyclophosphamide
- Remarks:
- TA 100, TA 1535 (with activation)
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation); preincubation
DURATION
- Preincubation period: 60 minutes
- Expression time (cells in growth medium): 48 hours
NUMBER OF REPLICATIONS: 3 plates for each test concentration
DETERMINATION OF CYTOTOXICITY
- Method: relative total growth; background lawn assessment - Evaluation criteria:
- A result is positive if the number of revertants is significantly increased compared with the solvent control to at least 2-fold of the solvent control for TA 98, TA 100 and TA 102 and 3-fold of the solvent control for TA 1535 and TA 1537 in both experiments.
Positive results have to be reproducible and the histidine independence of the revertants has to be confirmed by streaking on histidine-free agar plates. - Statistics:
- MANN and WHITNEY and Spearman’s rank.
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: S. typhimurium TA 1535, TA 1537, TA 98, TA 102 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- TA 1537 without activation only: 5000 µg/plate
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Additional information on results:
- COMPARISON WITH HISTORICAL CONTROL DATA: Results were within range of historical control data
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Table 2: Dose range-finding study (TA 100 – MA) Number of revertants per plate (2 plates)
|
TA100 |
||
Conc. |
Plate 1 |
Plate 2 |
Cytotoxic |
0* |
135 |
150 |
No |
0.316 |
123 |
122 |
No |
1 |
123 |
108 |
No |
3.16 |
109 |
124 |
No |
10 |
115 |
125 |
No |
31.6 |
148 |
114 |
No |
100 |
108 |
115 |
No |
316 |
105 |
121 |
No |
1000 |
109 |
105 |
No |
3160 |
106 |
150 |
No |
5000 |
118 |
125 |
No |
*Solvent control: Water
Table 3: Experiment 1 Plate incorporation Number of revertants per plate (mean of 3 plates)
|
TA98 |
TA100 |
TA102 |
||||||
Conc. |
— MA |
+ MA |
Cytotoxic |
— MA |
+ MA |
Cytotoxic |
— MA |
+ MA |
Cytotoxic |
0* |
35.3 |
32.7 |
No |
133 |
137.3 |
No |
293.3 |
280.7 |
No |
100 |
26.3 |
39 |
No |
125.3 |
140.7 |
No |
181.3 |
325.7 |
No |
316 |
36.7 |
32.7 |
No |
136.7 |
141 |
No |
290.3 |
317 |
No |
1000 |
37 |
43.7 |
No |
139.3 |
144.3 |
No |
298 |
319.7 |
No |
3160 |
30.7 |
31.3 |
No |
140.3 |
137.7 |
No |
308.7 |
315.3 |
No |
5000 |
37.3 |
48.7 |
No |
164 |
143.7 |
No |
317.7 |
333 |
No |
Positive control |
1170.3 |
1110 |
No |
1139.3 |
1241.3 |
No |
1094 |
1066.7 |
No |
*Solvent control: Water
Table 3: Experiment 1 Plate incorporation Number of revertants per plate (mean of 3 plates)
|
TA1535 |
TA1537 |
||||
Conc. |
— MA |
+ MA |
Cytotoxic |
— MA |
+ MA |
Cytotoxic |
0* |
13.3 |
17.7 |
No |
7.3 |
8 |
No |
100 |
13.7 |
18.3 |
No |
6 |
6 |
No |
316 |
16.7 |
17 |
No |
6.7 |
5.3 |
No |
1000 |
13.7 |
14.7 |
No |
7 |
5 |
No |
3160 |
13.7 |
14 |
No |
7 |
7.3 |
No |
5000 |
15 |
16 |
No |
5 |
6.7 |
No |
Positive control |
736 |
921.3 |
No |
885 |
893.7 |
No |
*Solvent control: Water
Table 4: Experiment 2 Preincubation Number of revertants per plate (mean of 3 plates)
|
TA98 |
TA100 |
TA102 |
||||||
Conc. |
— MA |
+ MA |
Cytotoxic |
— MA |
+ MA |
Cytotoxic |
— MA |
+ MA |
Cytotoxic |
0* |
30.3 |
24.3 |
No |
124 |
135 |
No |
285.7 |
280.3 |
No |
100 |
29.7 |
35.7 |
No |
114.7 |
132 |
No |
310.3 |
300 |
No |
316 |
31 |
38.3 |
No |
119.3 |
123.3 |
No |
312.3 |
309 |
No |
1000 |
28 |
34.3 |
No |
120.7 |
136 |
No |
320.3 |
296.7 |
No |
3160 |
31.3 |
35 |
No |
124.7 |
136 |
No |
301 |
289 |
No |
5000 |
27.7 |
33.3 |
No |
111.3 |
143 |
No |
245.7 |
298 |
No |
Positive control |
831.1 |
1110.7 |
No |
1218 |
1195.3 |
No |
1150.3 |
1161.7 |
No |
*Solvent control: Water
Table 4: Experiment 2 Preincubation Number of revertants per plate (mean of 3 plates)
|
TA1535 |
TA1537 |
||||
Conc. |
— MA |
+ MA |
Cytotoxic |
— MA |
+ MA |
Cytotoxic |
0* |
16 |
14 |
No |
8 |
6 |
No |
100 |
15 |
11.3 |
No |
4.3 |
5 |
No |
316 |
13.3 |
14.3 |
No |
5 |
7.3 |
No |
1000 |
16.3 |
13 |
No |
5 |
7 |
No |
3160 |
17 |
14 |
No |
6.7 |
5.7 |
No |
5000 |
12 |
16.3 |
No |
4 |
11.7 |
Yes |
Positive control |
884 |
888.3 |
No |
645.3 |
627 |
No |
*Solvent control: Water
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
In a valid and reliable study conducted in accordance with OECD 471 and under GLP, no mutagenic effect was observed for the test substance tested up to cytotoxic concentration in any of the test strains in a plate incorporation study with and without metabolic activation. The result was confirmed in a pre-incubation study. It is concluded that the test substance is negative for the induction of micronuclei under the conditions of the test.
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