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EC number: 245-485-1 | CAS number: 23202-81-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 April 2013 to 26 September 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Fully GLP compliant and in accordance with current test guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methylfuranoside
- IUPAC Name:
- Methylfuranoside
- Reference substance name:
- Methyl 5-deoxy-2,3-O-isopropylidene-β-D-ribofuranoside
- EC Number:
- 245-485-1
- EC Name:
- Methyl 5-deoxy-2,3-O-isopropylidene-β-D-ribofuranoside
- Cas Number:
- 23202-81-5
- Molecular formula:
- C9H16O4
- IUPAC Name:
- methyl 5-deoxy-2,3-O-isopropylidene-beta-D-ribofuranoside
- Test material form:
- other: Pale yellow liquid
- Details on test material:
- Name: Methylfuranoside
CAS number: 23202-81-5
Batch number: 201111082008
Quantity received: 1.5 kg
Purity: 99.7%
Expiry date: November 2013
Date of receipt: Not reported
Storage details: stored in a sealed container, at room temperature (15 to 30°C) in the dark
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- At 0 and 48 hours, duplicate ca 100 mL samples of freshly prepared test media were taken from the control and 125 mg/L test media for chemical analysis.
At 24 and 72 hours, duplicate samples (ca 100 mL) of the control and 125 mg/L test concentration were taken for chemical analysis from the old media.
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- The dilution water used for conducting the definitive test was de-chlorinated mains water that had been passed through particulate and activated carbon filters and treated with ozone (O3) to remove residual algal cells and fungal spores for improved water quality.
The initial range-finding test was conducted at nominal test substance concentrations of 1.25, 12.5 and 125 mg/L, under semi-static test conditions.
Based on the results of the range-finding test, a definitive test was conducted at a single nominal test substance concentration of 125 mg/L.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebrafish (Danio rerio)
- Source: University College, London (UCL), United Kingdom
- Age at study initiation (mean and range, SD): Not reported
- Length at study initiation (length definition, mean, range and SD): Mean - 2.95 cm, 2.7 - 3.1 cm
- Weight at study initiation (mean and range, SD): Mean 0.48 g, 0.29 - 0.60 g
- Feeding during test: Not fed during the test
- Food type: Not applicable
- Amount: Not applicable
- Frequency: Not applicable
ACCLIMATION
- Acclimation period: 12 days prior to start of test
- Acclimation conditions (same as test or not): Same as test
- Type and amount of food: Not reported
- Feeding frequency: Not reported
- Health during acclimation (any mortality observed): Healthy
Study design
- Test type:
- semi-static
- Water media type:
- not specified
- Limit test:
- yes
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- Total hardness as CaCO3 (mg/L): 0 hour - 65 mg/L, 24 hours (new) - 66 mg/L, 48 hours (new) - 49 mg/L, 72 hours (new) - 47 mg/L
- Test temperature:
- Control: 0 hour - 23.6°C, 24 hours (old) - 23.4°C, 24 hours (new) - 23.4°C, 48 hours (old) - 23.7°C, 48 hours (new) - 23.2°C, 72 hours (old) - 23.4°C, 72 hours (new) - 23.3°C, 96 hours - 24.0°C
125 mg/L test substance: 0 hour - 23.2°C, 24 hours (old) - 23.5°C, 24 hours (new) - 23.3°C, 48 hours (old) - 23.5°C, 48 hours (new) - 23.3°C, 72 hours (old) - 23.5°C, 72 hours (new) - 23.2°C, 96 hours - 24.1°C - pH:
- Control: 0 hour - 7.03, 24 hours (old) - 7.28, 24 hours (new) - 7.27, 48 hour (old) - 7.08, 48 hours (new) - 7.06, 72 hours (old) - 7.34, 72 hours (new) - 7.19, 96 hours - 7.27
125 mg/L test substance: 0 hour - 7.04, 24 hours (old) - 7.30, 24 hours (new) - 7.14, 48 hours (old) - 7.11, 48 hours (new) - 7.05, 72 hours (old) - 7.37, 72 hours (new) - 7.19, 96 hours - 7.33 - Dissolved oxygen:
- Dissolved oxygen % ASV (mg/L)
Control: 0 hour - 101 (8.64), 24 hours (old) - 99 (8.27), 24 hours (new) - 110 (9.28), 48 hours (old) - 95 (7.82), 48 hours (new) - 100 (8.26), 72 hours (old) - 95 (8.10), 72 hours (new) - 106 (8.78), 96 hours - 95 (8.20)
125 mg/L test substance: 0 hour - 101 (8.61), 24 hours (old) - 97 (8.12), 24 hours (new) - 109 (9.14), 48 hours (old) - 95 (7.84), 48 hours (new) - 100 (8.24), 72 hours (old) - 107 (8.79), 72 hours (new) - 107 (8.79), 96 hours - 95 (8.10) - Salinity:
- Not reported
- Nominal and measured concentrations:
- Nominal concentration - 125 mg/L
0 hours (new media) - 89.79 mg/L (72% nominal)
24 hours (old meadia) - 123.18 mg/L ( 99% nominal)
48 hours (new media) - 122.82 mg/L (98% nominal)
72 hours (old media) - 126.09 mg/L (101% nominal) - Details on test conditions:
- TEST SYSTEM
- Test vessel: 2.5 L constructed glass aquaria containing 10 L of the appropriate test media, fitted with clear plastic lids
- Material, size, headspace, fill volume: 7 L of appropriate test media
- Aeration: Not applicable
- Renewal rate of test solution (frequency/flow rate): 24 hourly
- No. of organisms per vessel: Three
- No. of vessels per concentration (replicates): Single
- No. of vessels per control: Single
- Biomass loading rate: 0.69 g/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Treated mains water, in laboratory
- Intervals of water quality measurement: At the start of the test and every 24 hours
OTHER TEST CONDITIONS
- Adjustment of pH: Not applicable
- Photoperiod: Not reported
- Light intensity: Not reported
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : All fish in each test vessel were observed at ca 4.5 hours and then at 24-hour intervals (24, 48, 72 and 96 hours) throughout the duration of the test. The number of dead fish and those fish exhibiting toxic symptoms or modified behaviour were recorded, if applicable.
TEST CONCENTRATIONS
- Range finding study: The initial range-finding test was conducted at nominal test substance concentrations of 1.25, 12.5 and 125 mg/L, under semi-static test conditions. A control group containing treated mains water only was also included.
- Results used to determine the conditions for the definitive study: Based on the results of the range-finding test, a definitive test was conducted at a single nominal test substance concentration of 125 mg/L
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC10
- Effect conc.:
- > 115 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- other: LC20
- Effect conc.:
- > 115 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 115 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 115 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- Chemical analysis
The limit of detection (LOD) for Methylfuranoside in treated mains water using this method was 0.043 mg/L.
Analysis of the fresh media at 0 and 48 hours showed measured concentrations of 72% and 98% of nominal, respectively. Analysis of the corresponding old media at 24 and 72 hours showed measured concentrations of 99% and 101% of nominal, respectively. The mean measured concentration was calculated to be 115 mg/L (equivalent to 92% of nominal value). The results have therefore been based on mean measured test concentrations.
Toxicity
The EC10, EC20 and EC50 values were determined to be greater than 115 mg/L.
Based on mean measured concentrations, the 96-hour NOEC was considered to be 115 mg/L.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96-hour acute toxicity of Methylfuranoside to the freshwater fish species Danio rerio was determined under semi-static test conditions in accordance with the requirements of OECD Chemicals Testing Guideline No. 203 Fish, Acute Toxicity Test (adopted 17 July 1992).
All validity criteria were satisfied, therefore the test was considered valid.
The 96-hour LC50 value was considered to be greater than 115 mg/L, based on mean measured test concentrations. The NOEC was considered to be 115 mg/L.
It is concluded that Methylfuranoside was considered non toxic to Danio rerio at nominal concentrations less than 125 mg/L under the conditions of this test. - Executive summary:
The objective of the study was to determine the 96-hour acute toxicity of Methylfuranoside to Danio rerio. The study was conducted in accordance with the requirements of OECD Chemicals Testing Guideline No.203 Fish, Acute Toxicity Test (adopted 17 July 1992).
Based on the results of a range-finding test, which are not fully reported, the definitive test was conducted at a single nominal test concentration of 125 mg/L.
The study was conducted using a semi-static test design with daily renewal of test media during the test.
Analysis of the fresh media at 0 and 48 hours showed measured concentrations of 72% and 98% of nominal, respectively. Analysis of the corresponding old media at 24 and 72 hours showed measured concentrations of 99% and 101% of nominal, respectively. The mean measured concentration was calculated to be 115 mg/L (equivalent to 92% of nominal value). The results have therefore been based on mean measured test concentrations.
[1] LC 10, 20 and 50 values and the corresponding [2] NOEC values are presented in the following table. Values are presented in terms of nominal concentrations.
Parameter
Mean Measured Concentrations (mg/L)
24 hours
48 hours
72 hours
96 hours
LC10
>115
>115
>115
>115
LC20
>115
>115
>115
>115
LC50
>115
>115
>115
>115
NOEC
115
115
115
115
Based on mean measured test concentrations, the EC10, EC20 and EC50 values were determined to be greater than 115 mg/L.Based on mean measured test concentrations, the 96-hour NOEC was considered to be 115 mg/L.
The validity criteria for control mortality and dissolved oxygen (>60% ASV) were both satisfied. The test was therefore considered to be valid.
It is concluded thatMethylfuranoside was considerednon toxic to Danio rerio at nominal concentrations less than 125 mg/L under the conditions of this test.
[1] Lethal concentration resulting in 10, 20 and 50% mortality
[2] No Observed Effect Concentration
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