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EC number: 252-328-0 | CAS number: 35037-73-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- 4-Trifluoromethoxyphenyl isocyanate was applied semiocclusive 50 , 100, 150, 250, 500, 1000 or 1500 µl/kg bw (male rats) and 50, 100, 250, 500, 1500, or 2500 µl/kg bw (female rats) to five or ten male or female Wister rats for 24 hours. The animals were observed for mortality and clinical signs through day 14. A gross pathological examination was performed on animals which died intercurrent or were killed after termination of the study.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- p-(trifluoromethoxy)phenyl isocyanate
- EC Number:
- 252-328-0
- EC Name:
- p-(trifluoromethoxy)phenyl isocyanate
- Cas Number:
- 35037-73-1
- Molecular formula:
- C8H4F3NO2
- IUPAC Name:
- 1-isocyanato-4-(trifluoromethoxy)benzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: undiluted or with cellulose powder
- Duration of exposure:
- 24 hours
- Doses:
- male rats: 50 , 100, 150, 250, 500, 1000 or 1500 µl/kg bw = 67, 134, 201, 335, 670, 1340, 2010 mg/kg bw
female rats: 50, 100, 250, 500, 1500, or 2500 µl/kg bw = 67, 134, 335, 670, 20103350 mg/kg bw - No. of animals per sex per dose:
- male rats: 50 µl/kg bw = 5 animals; 100, 150, 250, 500, 1000 or 1500 µl/kg bw = 10 animals
female rats: 50, 2500 µl/kg bw = 5 animals; 100, 250, 500, 1500 µl/kg bw = 10 animals - Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 268 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 670 mg/kg bw
- Based on:
- test mat.
- Other findings:
- Signs of intoxiciation: increased motility, afterwards decreased motility, aggresivity, laboured breathing, weekness of hind limbs, partly strong weight loss.
Start of the symptoms: 5 to 20 minutes after application. Duration of the symptoms: 2 to 6 days. The surviving animals showed afterwards apathy up to 14 days
Necropsy findings on animals died intercurrent: , liver pale and mottled, kidneys pale, renal plevis partly reddened, in the urinary bladder partly red urine, intestine with dark, mucous content.
Necropsy findings on animals killed after post-observation period: on animals with weekness of hind limbs the renal pelvis was destroyed, bloody urine, other internal organs macroscopically without findings
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- Based on EU GHS criteria.
- Conclusions:
- Signs of intoxication were apathy, decreased motolity, cyanosis, laboured breathing and cramps. The LD50 for female rats was ca. 670 mg/kg bw and the LD50 for male rats was 238 mg/kg bw.
- Executive summary:
Acute toxicity dermal test was done similarly to OECD guideline 402. 4-Trifluoromethoxyphenyl isocyanate was applied semiocclusive 50 , 100, 150, 250, 500, 1000 or 1500 µL/kg bw (male rats) and 50, 100, 250, 500, 1500, or 2500 µL/kg bw (female rats) to five or ten male or female Wister rats for 24 hours. The animals were observed for mortality and clinical signs through day 14. A gross pathological examination was performed on animals which died intercurrent or were killed after termination of the study.
Signs of intoxication were apathy, decreased motolity, cyanosis, laboured breathing and cramps. The LD50 for female rats was ca. 670 mg/kg bw and the LD50 for male rats was 238 mg/kg bw.
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