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EC number: 213-485-0 | CAS number: 957-68-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 27, 2012 - September 18, 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study (OECD102) with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- thermal analysis
Test material
- Reference substance name:
- 3-acetoxymethylen-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- EC Number:
- 213-485-0
- EC Name:
- 3-acetoxymethylen-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Cas Number:
- 957-68-6
- Molecular formula:
- C10H12N2O5S
- IUPAC Name:
- (6R,7R)-3-[(acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): 7-Aminocephalosporanic acid
- Lot/batch No.: B146988
Constituent 1
Results and discussion
Melting / freezing point
- Decomposition:
- yes
- Decomp. temp.:
- >= 180 °C
Any other information on results incl. tables
In all three measurements a broad exothermal effect could be observed in a temperature range of 190 – 360 °C with a decomposition energy of -190 J/g (mean value). In all three measurements amass loss of approximately 68 % could be observed.
Table: Results on melting and boiling point
No. |
Sample weight / mg |
Start of effect / °C |
Energy / |
Remark |
PN4233 |
13.94 |
200 |
-190 (exothermal) |
|
PN4242 |
10.58 |
210 |
-170 (exothermal) |
|
PN4262 |
12.04 |
190 |
-210(exothermal) |
Applicant's summary and conclusion
- Conclusions:
- According to OECD Test Guidelines 102 and 103, and EC No. 440/2008 Part A. Method A.1. and A.2., the test item 7-Aminocephalosporanic acid has no melting and no boiling point at atmospheric pressure (1013 hPa). It decomposes firstly at a temperature of 180 °C.
- Executive summary:
In this test, the thermal stability and the melting and boiling temperatures of the test item were investigated by DSC (differential scanning calorimetry). With this method the difference in energy input into the test item and a reference material as a function of temperature was recorded, while the substance and reference material were subjected to the same temperature program. This energy was the energy necessary to establish zero temperature difference between the substance and the reference material. When the sample underwent a transition involving a change of enthalpy, that change was indicated by an endothermic departure (e.g. melting, boiling) from the base line of the heat flow record. As result, a thermogram was created in which the transition heat flow was exhibited as a function of the temperature. In this diagram, the onset of the process (e.g. decomposition, physical process) as well as the heat flow of the process was shown.
For the first two tests the test item was weighed in under air into aluminium crucibles. About 11 ‑ 14 mg of the test item were weighed in for the tests. The crucible was closed with a cover. In the cover was a small hole. As reference crucibles, empty aluminium crucibles were used.
For one further test the test item was weighed in under air into a glass crucible. About 12 mg of the test item were weighed in for the test. The upper end of the crucible was closed by melting with an oxyhydrogen flame and opened afterwards by breaking off the top. As reference crucibles, glass crucibles with aluminium oxide were used.
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