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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guidline study with accepted restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Principles of method if other than guideline:
According to Fed Reg 38 No.187 § 1500.41
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Propionic acid
EC Number:
201-176-3
EC Name:
Propionic acid
Cas Number:
79-09-4
Molecular formula:
C3H6O2
IUPAC Name:
propanoic acid
Details on test material:
- Name of test material (as cited in study report): Propanoic add; propionic acid; CP 66423
- Analytiucal purity: no data
- D-1 Product 5/7/75

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 µl
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
14 days
Number of animals or in vitro replicates:
6
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no

SCORING SYSTEM: no data


TOOL USED TO ASSESS SCORE: no data

Results and discussion

In vivo

Results
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 1 min
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: corrosive with in 1 min. No evaluation of iris, erythema and chemiosis was done therefore
Irritant / corrosive response data:
Immediately after instillation: Severe discomfort with pawing, squealing, and thrashing about the stock
After 1 min: Corrosive
After 14 days: Ulceration

Applicant's summary and conclusion