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EC number: 202-681-1 | CAS number: 98-56-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March-April 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Remarks:
- liver function was the focal parameter
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 6 rabbits were applied with a single dose of the test item on the shaved neck skin for 5 hours and observed for 7 days. Before the application and at day 1, 3 and 7, the activity of aspartate- and alanine aminotransfrase (AST and ALT) were measured in the peripheral blood. The survived animals were sacrificed at the end of the study and their liver was analyzed for hystologic abnormalities.
- GLP compliance:
- no
- Test type:
- other: liver functioning assessment after single dermal application
- Limit test:
- yes
Test material
- Reference substance name:
- 4-chloro-α,α,α-trifluorotoluene
- EC Number:
- 202-681-1
- EC Name:
- 4-chloro-α,α,α-trifluorotoluene
- Cas Number:
- 98-56-6
- Molecular formula:
- C7H4ClF3
- IUPAC Name:
- 1-chloro-4-(trifluoromethyl)benzene
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 1.5 - 2 kg
- Housing: in single cages and with a plastic collar allowing to avoid the oral contact with the treated skin area
IN-LIFE DATES: From: 29 march 1976 To: 6 april 1976
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- REMOVAL OF TEST SUBSTANCE
- Washing: with a sponge and cold water
- Time after start of exposure: 5 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 5000 g - Duration of exposure:
- 5 h
- Doses:
- 5000 mg
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: blood was collected and analysed for AST and ALT activity on days: 0, 1, 3 and 7
- Necropsy of survivors performed: yes
- Other examinations performed: mortality, beahviour, micro and macroscopic examination of the liver
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 3 300 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality
- Clinical signs:
- other: No clinical sign reported
- Gross pathology:
- No abnormality reported
- Other findings:
- After 24 hours the activities of of AST and ALT were slightly increased, but this effect was fully reversible whithin 7 days after the application.
Any other information on results incl. tables
Liver functioning parameters before and after the test item dermal application
|
AST |
ALT |
||||||
|
Initial value |
t = 24 h |
t = 3 d |
t = 7 d |
Initial value |
t = 24 h |
t = 3 d |
t = 7 d |
n |
6 |
6 |
6 |
6 |
6 |
6 |
6 |
6 |
mean |
4.7 |
14 |
5.3 |
2.3 |
31.3 |
57.5 |
41.7 |
31.7 |
S.D. |
2.1 |
4.7 |
1.2 |
0.5 |
4.0 |
10.3 |
5.1 |
4.1 |
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP criteria not met
- Conclusions:
- PCBTF exerted no adverse effect to rabbits after dermal application of 5000 mg for 5 hours. After 24 hours the activities of AST and ALT were slightly increased, but this effect was fully reversible whithin 7 days. No mortality, neither abnormal behaviour were observed during the 7 -days post-application period. No micro-, nor macroscopic findings were observed after hystological liver analysis.
- Executive summary:
6 rabbits were applied with a single dose of the test item on the shaved neck skin for 5 hours and observed for 7 days afterwards. Before the application and at day 1, 3 and 7, the activities of aspartate- and alanine aminotransfrase (AST and ALT) were measured in the peripheral blood. After 24 hours the activities of AST and ALT were slightly increased, but this effect was fully reversible whithin 7 days after the application. No mortality, neither abnormal behaviour were observed during the 7 -days period. The survived animals were sacrificed at the end of the study and their liver was analyzed for hystologic abnormalities. No micro-, nor macroscopic findigs were reported.
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